Ultimate biodegradability and ecotoxicity of orally administered antidiabetic drugs
Marta Markiewicz , Christian Jungnickel , Stefan Stolte , Anna Białk-Bielińska , Jolanta Kumirska , Wojciech Mrozik
AbstractHypoglycaemic pharmaceuticals are recently more and more frequently detected in the environment. In our previous study, we have shown that even though many of them undergo significant primary degradation some are transformed to stable products or undergo such transformation that a large part of the structure is still preserved. One of the main routes of elimination from wastewaters or surface waters is biodegradation and a lack thereof leads to accumulation in the environment. Within this work we tested the ultimate biodegradability of six oral antidiabetics: metformin and its main metabolite guanylurea, acarbose, glibenclamide, gliclazide, glimepiride and repaglinide. We also compared the experimental results obtained in this and accompanying work with models designed to predict biodegradability and showed that these models are only moderately successful. Additionally, we examined these compounds in acute Daphnia magna test to check if they might pose an ecotoxicological threat. Combining the results of biodegradability and toxicity tests allows a preliminary assessment of their potential environmental impact.
|Other language title versions|
|Journal series||Journal of Hazardous Materials, ISSN 0304-3894|
|Publication size in sheets||0.5|
|Keywords in English||biodegradation, ecotoxicity, pharmaceuticals, antidiabetic drugs, sulphonamides|
|Score|| = 45.0, 20-12-2017, ArticleFromJournal|
= 45.0, 20-12-2017, ArticleFromJournal
|Publication indicators||: 2016 = 6.065 (2) - 2016=6.393 (5)|
* presented citation count is obtained through Internet information analysis and it is close to the number calculated by the Publish or Perish system.