Ultimate biodegradability and ecotoxicity of orally administered antidiabetic drugs

Marta Markiewicz , Christian Jungnickel , Stefan Stolte , Anna Białk-Bielińska , Jolanta Kumirska , Wojciech Mrozik

Abstract

Hypoglycaemic pharmaceuticals are recently more and more frequently detected in the environment. In our previous study, we have shown that even though many of them undergo significant primary degradation some are transformed to stable products or undergo such transformation that a large part of the structure is still preserved. One of the main routes of elimination from wastewaters or surface waters is biodegradation and a lack thereof leads to accumulation in the environment. Within this work we tested the ultimate biodegradability of six oral antidiabetics: metformin and its main metabolite guanylurea, acarbose, glibenclamide, gliclazide, glimepiride and repaglinide. We also compared the experimental results obtained in this and accompanying work with models designed to predict biodegradability and showed that these models are only moderately successful. Additionally, we examined these compounds in acute Daphnia magna test to check if they might pose an ecotoxicological threat. Combining the results of biodegradability and toxicity tests allows a preliminary assessment of their potential environmental impact.
Author Marta Markiewicz
Marta Markiewicz,,
-
, Christian Jungnickel
Christian Jungnickel,,
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, Stefan Stolte (FCh / DEA / LChER)
Stefan Stolte,,
- Laboratory of Chemical Environmental Risks
, Anna Białk-Bielińska (FCh / DEA / LChER)
Anna Białk-Bielińska,,
- Laboratory of Chemical Environmental Risks
, Jolanta Kumirska (FCh / DEA / LChAD)
Jolanta Kumirska,,
- Laboratory of Chemical Analytics and Diagnostics
, Wojciech Mrozik
Wojciech Mrozik,,
-
Other language title versions
Journal seriesJournal of Hazardous Materials, ISSN 0304-3894, (A 45 pkt)
Issue year2017
Vol333
Pages154-161
Publication size in sheets0.5
Keywords in Englishbiodegradation, ecotoxicity, pharmaceuticals, antidiabetic drugs, sulphonamides
DOIDOI:10.1016/j.jhazmat.2017.03.030
URL http://doi.org/10.1016/j.jhazmat.2017.03.030
Languageen angielski
Score (nominal)45
ScoreMinisterial score = 45.0, 20-12-2017, ArticleFromJournal
Ministerial score (2013-2016) = 45.0, 20-12-2017, ArticleFromJournal
Publication indicators WoS Impact Factor: 2016 = 6.065 (2) - 2016=6.393 (5)
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* presented citation count is obtained through Internet information analysis and it is close to the number calculated by the Publish or Perish system.
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