Characterization and cytotoxic effect of aqua-(2,2′,2′′-nitrilotriacetato)-oxo-vanadium salts on human osteosarcoma cells
Aleksandra Tesmar , Dariusz Wyrzykowski , Rafał Kruszyński , Karolina Niska , Iwona Inkielewicz-Stępniak , Joanna Drzeżdżon , Dagmara Jacewicz , Lech Chmurzyński
AbstractThe use of protonated N-heterocyclic compound, i.e. 2,2′-bipyridinium cation, [bpyH+], enabled to obtain the new nitrilotriacetate oxidovanadium(IV) salt of the stoichiometry [bpyH][VO(nta)(H2O)]H2O. The X-ray measurements have revealed that the compound comprises the discrete mononuclear [VO(nta)(H2O)]− coordination ion that can be rarely found among other known compounds containing nitrilotriacetate oxidovanadium(IV) moieties. The antitumor activity of [bpyH][VO(nta)(H2O)]H2O and its phenanthroline analogue, [phenH][VO(nta)(H2O)](H2O)0.5, towards human osteosarcoma cell lines (MG-63 and HOS) has been assessed (the LDH and BrdU tests) and referred to cis-Pt(NH3)2Cl2 (used as a positive control). The compounds exert a stronger cytotoxic effect on MG-63 and HOS cells than in untransformed human osteoblast cell line. Thus, the [VO(nta)(H2O)]− containing coordination compounds can be considered as possible antitumor agents in the osteosarcoma model of bone-related cells in culture.
|Journal series||Biometals, ISSN 0966-0844, (A 25 pkt)|
|Publication size in sheets||0.7|
|Keywords in English||vanadium, osteosarcoma cells, antitumor activity, crystal structure, potentiometric titration|
|License||Journal (articles only); published final; ; with publication|
|Score|| = 25.0, 20-12-2017, ArticleFromJournal|
= 30.0, 20-12-2017, ArticleFromJournal
|Publication indicators||: 2016 = 2.183 (2) - 2016=2.477 (5)|
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