Characterization and cytotoxic effect of aqua-(2,2′,2′′-nitrilotriacetato)-oxo-vanadium salts on human osteosarcoma cells

Aleksandra Tesmar , Dariusz Wyrzykowski , Rafał Kruszyński , Karolina Niska , Iwona Inkielewicz-Stępniak , Joanna Drzeżdżon , Dagmara Jacewicz , Lech Chmurzyński

Abstract

The use of protonated N-heterocyclic compound, i.e. 2,2′-bipyridinium cation, [bpyH+], enabled to obtain the new nitrilotriacetate oxidovanadium(IV) salt of the stoichiometry [bpyH][VO(nta)(H2O)]H2O. The X-ray measurements have revealed that the compound comprises the discrete mononuclear [VO(nta)(H2O)]− coordination ion that can be rarely found among other known compounds containing nitrilotriacetate oxidovanadium(IV) moieties. The antitumor activity of [bpyH][VO(nta)(H2O)]H2O and its phenanthroline analogue, [phenH][VO(nta)(H2O)](H2O)0.5, towards human osteosarcoma cell lines (MG-63 and HOS) has been assessed (the LDH and BrdU tests) and referred to cis-Pt(NH3)2Cl2 (used as a positive control). The compounds exert a stronger cytotoxic effect on MG-63 and HOS cells than in untransformed human osteoblast cell line. Thus, the [VO(nta)(H2O)]− containing coordination compounds can be considered as possible antitumor agents in the osteosarcoma model of bone-related cells in culture.
Author Aleksandra Tesmar PFZK
Aleksandra Tesmar,,
- Laboratory of Physicochemistry of Coordination Complexes
, Dariusz Wyrzykowski PBChN
Dariusz Wyrzykowski,,
- Pracownia Biologicznej Chemii Nieorganicznej
, Rafał Kruszyński
Rafał Kruszyński,,
-
, Karolina Niska
Karolina Niska,,
-
, Iwona Inkielewicz-Stępniak
Iwona Inkielewicz-Stępniak,,
-
, Joanna Drzeżdżon PFZK
Joanna Drzeżdżon,,
- Laboratory of Physicochemistry of Coordination Complexes
, Dagmara Jacewicz PFZK
Dagmara Jacewicz,,
- Laboratory of Physicochemistry of Coordination Complexes
, Lech Chmurzyński PFZK
Lech Chmurzyński,,
- Laboratory of Physicochemistry of Coordination Complexes
Journal seriesBiometals, ISSN 0966-0844
Issue year2017
Vol30
No2
Pages261-275
Publication size in sheets0.7
Keywords in Englishvanadium, osteosarcoma cells, antitumor activity, crystal structure, potentiometric titration
DOIDOI:10.1007/s10534-017-0001-6
URL https://link.springer.com/content/pdf/10.1007%2Fs10534-017-0001-6.pdf
Languageen angielski
Score (nominal)30
ScoreMinisterial score = 25.0, 20-12-2017, ArticleFromJournal
Ministerial score (2013-2016) = 30.0, 20-12-2017, ArticleFromJournal
Publication indicators WoS Impact Factor: 2016 = 2.183 (2) - 2016=2.477 (5)
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