Characterization and cytotoxic effect of aqua-(2,2′,2′′-nitrilotriacetato)-oxo-vanadium salts on human osteosarcoma cells

Aleksandra Tesmar , Dariusz Wyrzykowski , Rafał Kruszyński , Karolina Niska , Iwona Inkielewicz-Stępniak , Joanna Drzeżdżon , Dagmara Jacewicz , Lech Chmurzyński


The use of protonated N-heterocyclic compound, i.e. 2,2′-bipyridinium cation, [bpyH+], enabled to obtain the new nitrilotriacetate oxidovanadium(IV) salt of the stoichiometry [bpyH][VO(nta)(H2O)]H2O. The X-ray measurements have revealed that the compound comprises the discrete mononuclear [VO(nta)(H2O)]− coordination ion that can be rarely found among other known compounds containing nitrilotriacetate oxidovanadium(IV) moieties. The antitumor activity of [bpyH][VO(nta)(H2O)]H2O and its phenanthroline analogue, [phenH][VO(nta)(H2O)](H2O)0.5, towards human osteosarcoma cell lines (MG-63 and HOS) has been assessed (the LDH and BrdU tests) and referred to cis-Pt(NH3)2Cl2 (used as a positive control). The compounds exert a stronger cytotoxic effect on MG-63 and HOS cells than in untransformed human osteoblast cell line. Thus, the [VO(nta)(H2O)]− containing coordination compounds can be considered as possible antitumor agents in the osteosarcoma model of bone-related cells in culture.
Author Aleksandra Tesmar (FCh / DGICh / LPCC)
Aleksandra Tesmar,,
- Laboratory of Physicochemistry of Coordination Complexes
, Dariusz Wyrzykowski (FCh / DGICh / PBChN)
Dariusz Wyrzykowski,,
- Pracownia Biologicznej Chemii Nieorganicznej
, Rafał Kruszyński
Rafał Kruszyński,,
, Karolina Niska
Karolina Niska,,
, Iwona Inkielewicz-Stępniak
Iwona Inkielewicz-Stępniak,,
, Joanna Drzeżdżon (FCh / DGICh / LPCC)
Joanna Drzeżdżon,,
- Laboratory of Physicochemistry of Coordination Complexes
, Dagmara Jacewicz (FCh / DGICh / LPCC)
Dagmara Jacewicz,,
- Laboratory of Physicochemistry of Coordination Complexes
, Lech Chmurzyński (FCh / DGICh / LPCC)
Lech Chmurzyński,,
- Laboratory of Physicochemistry of Coordination Complexes
Journal seriesBiometals, ISSN 0966-0844, (A 25 pkt)
Issue year2017
Publication size in sheets0.7
Keywords in Englishvanadium, osteosarcoma cells, antitumor activity, crystal structure, potentiometric titration
ASJC Classification2506 Metals and Alloys; 1100 General Agricultural and Biological Sciences; 1300 General Biochemistry, Genetics and Molecular Biology; 2502 Biomaterials
Languageen angielski
LicenseJournal (articles only); published final; Uznanie Autorstwa (CC-BY); with publication
Score (nominal)25
ScoreMinisterial score = 25.0, 24-07-2019, ArticleFromJournal
Publication indicators Scopus SNIP (Source Normalised Impact per Paper): 2016 = 0.734; WoS Impact Factor: 2017 = 2.478 (2) - 2017=2.648 (5)
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* presented citation count is obtained through Internet information analysis and it is close to the number calculated by the Publish or Perish system.