Biophysical characterization of the complexation of C60 fullerene with doxorubicin in a prokaryotic model

Y. Prylutskyy , Agnieszka Borowik , Grzegorz Gołuński , Anna Woziwodzka , Jacek Piosik , O. Kyzyma , I. Pashkova , U. Ritter , M. Evstigneev


By means of small‐angle neutron scattering and ames mutagenicity test it was shown that C60 fullerene may act as an interceptor of the antibiotic doxorubicin by formation of a hetero‐complex with this drug. This result has been predicted based on previously developed model of chemico‐biological interaction between DNA‐binding drugs and aromatic interceptor molecules.
Author Y. Prylutskyy
Y. Prylutskyy,,
, Agnieszka Borowik (IFB)
Agnieszka Borowik,,
- Intercollegiate Faculty of Biotechnology UG
, Grzegorz Gołuński (IFB)
Grzegorz Gołuński,,
- Intercollegiate Faculty of Biotechnology UG
, Anna Woziwodzka (IFB / M020 / DMCB)
Anna Woziwodzka,,
- Department of Molecular and Cellular Biology
, Jacek Piosik (IFB / M020 / DMCB)
Jacek Piosik,,
- Department of Molecular and Cellular Biology
, O. Kyzyma
O. Kyzyma,,
, I. Pashkova
I. Pashkova,,
, U. Ritter
U. Ritter,,
, M. Evstigneev
M. Evstigneev,,
Other language title versionsBiophysikalische Charakterisierung der Komplexierung von C60‐Fulleren mit Doxorubicin in einem prokaryotischen Modell
Journal seriesMaterialwissenschaft und Werkstofftechnik, ISSN 0933-5137, (A 15 pkt)
Issue year2016
Publication size in sheets0.5
Keywords in EnglishC60 fullerene, doxorubicin, mutagenicity, small-angle neutron scattering
Languageen angielski
Score (nominal)15
ScoreMinisterial score = 15.0, 20-12-2017, ArticleFromJournal
Ministerial score (2013-2016) = 15.0, 20-12-2017, ArticleFromJournal
Publication indicators WoS Impact Factor: 2016 = 0.524 (2) - 2016=0.574 (5)
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* presented citation count is obtained through Internet information analysis and it is close to the number calculated by the Publish or Perish system.