Salinity and pH as factors affecting the passive sampling and extraction of pharmaceuticals from water

Hanna Lis , Piotr Stepnowski , Magda Caban


Passive sampling is an attractive technique for the long‐term monitoring of pharmaceuticals in the water environment. The reliability of the received results depends on the properly performed calibration, namely the determination of analyte sampling rates. This step can be the source of a systematic error, as the sampling rate values are dependent on the water donor phase parameters. This is especially important for pharmaceuticals, since their chemical characteristics and ionic form change with pH. In this study, the cross‐effect of pH (3, 7 and 9) and salinity (0, 7 and 35 practical salinity unit, using artificial sea water) on the passive sampling of 21 pharmaceuticals (antiparasitics, beta‐blockers, non‐steroidal anti‐inflammatory drugs, sulfonamides) was tested. The primarily determined parameter was the sampling rate. In addition, the extraction efficiency, partitioning coefficient, and the concentration of the analytes on the sorbent were calculated. Generally, for the non‐steroidal anti‐inflammatory drugs, beta‐blockers, and antiparasitics, the change both in pH and salinity had a negligible impact on the mentioned experimental parameters. In contrast, the extraction of sulfonamides was impacted by both pH and salinity, while lipophilicity was not a decisive parameter.
Author Hanna Lis (FCh / DEA / PAiMŚ)
Hanna Lis,,
- Pracownia Analityki i Monitoringu Środowiska
, Piotr Stepnowski (FCh / DEA / LChER)
Piotr Stepnowski,,
- Laboratory of Chemical Environmental Risks
, Magda Caban (FCh / DEA / PAiMŚ)
Magda Caban,,
- Pracownia Analityki i Monitoringu Środowiska
Journal seriesJournal of Separation Science, ISSN 1615-9306, (N/A 70 pkt)
Issue year2019
Keywords in Englishhydrophilic-lipophilic balance, passive sampling, pharmaceuticals, pH effect, salinity effect
ASJC Classification1506 Filtration and Separation; 1602 Analytical Chemistry
Languageen angielski
Score (nominal)70
Score sourcejournalList
ScoreMinisterial score = 70.0, 27-03-2020, ArticleFromJournal
Publication indicators WoS Citations = 0; Scopus Citations = 0; Scopus SNIP (Source Normalised Impact per Paper): 2018 = 0.762; WoS Impact Factor: 2018 = 2.516 (2) - 2018=2.209 (5)
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