Antimicrobial peptides (AMPs) as drug candidates : a patent review (2003-2015)

Palina Kosikowska , Adam Lesner

Abstract

Introduction: Antimicrobial peptides (AMPs) represent the large group of endogenous compounds widely distributed in nature. Due to their broad spectrum of antibiotic activity, as well as anti-inflammatory and immunomodulatory properties, AMPs became a model for the discovery of novel antimicrobial drugs that could answer the problem of the increasing antibiotic resistance of pathogenic microorganisms. Areas covered: The review represents a comprehensive analysis of patents and patent applications from the year 2003 to 2015 referring to the therapeutic use of AMPs. The article highlights the general trends in the design, potential mode of action, and methods of biological evaluation of AMPs. Expert opinion: The existing discord between the upcoming list of antimicrobial peptides claimed in the patents or related scientific articles as the potent drug candidates and the frequent failures of AMPs in clinical trials emphasize the need of a better understanding of their pleiotropic nature and mechanisms of host defense in general. Nevertheless, the encouraging examples of AMPs already introduced into the market, like Polymyxin or Fuzeon®, give some reason for optimism that development of AMPs as a novel class of antibiotics is still considered viable.
Author Palina Kosikowska PAB
Palina Kosikowska,,
- Laboratory of Biochemical Analytics
, Adam Lesner PAB
Adam Lesner,,
- Laboratory of Biochemical Analytics
Journal seriesExpert Opinion on Therapeutic Patents, ISSN 1354-3776
Issue year2016
Vol26
No6
Pages689-702
Publication size in sheets0.65
Keywords in Englishpeptides, peptidomimetics, therapies, antimicrobials, bacteriostatics
DOIDOI:10.1080/13543776.2016.1176149
Languageen angielski
Score (nominal)35
ScoreMinisterial score = 35.0, 20-12-2017, ArticleFromJournal
Ministerial score (2013-2016) = 35.0, 20-12-2017, ArticleFromJournal
Publication indicators WoS Impact Factor: 2016 = 3.041 (2) - 2016=3.519 (5)
Citation count*41 (2018-08-19)
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* presented citation count is obtained through Internet information analysis and it is close to the number calculated by the Publish or Perish system.
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