Pregnancy at advanced maternal age affects behavior and hippocampal gene expression in mouse offspring

Silvestre Sampino , Adrian Mateusz Stankiewicz , Federica Zacchini , Joanna Gościk , Agnieszka Szostak , Artur Hugo Świergiel , Drago Gaspare , Jacek Andrzej Modliński , Grażyna Ewa Ptak

Abstract

There is growing evidence that advanced maternal age is a risk factor for neurological and neuropsychiatric disorders in offspring. However, it remains unclear whether the altered brain programming induced by advanced maternal age is mediated by pre- or postnatal factors. Here, a mouse model was used to investigate whether pregnancy at advanced age may provoke behavioral and brain gene expression changes in offspring. Swiss Albino mice conceived by 3-month-old males and either 15–18-month-old (n = 11) or 3-month-old control females (n= 5), were delivered by cesarean section, fostered after birth by 3-month-old dams and subjected to a battery of behavioral tests. Furthermore, genome-wide mRNA expression was analyzed in the hippocampi of 4-month-old males offspring using microarrays. Offspring conceived by old mothers exhibited increased ultrasound vocalization activity during separation from the foster mother, increased anxiety-like behaviors in adult life, and altered patterns of hippocampal gene expression, compared to controls. These effects were not reversed by the postnatal maternal care provided by the young foster mothers, suggesting that the altered brain programming is already established at birth, consistent with prenatal effects related to maternal aging.
Author Silvestre Sampino
Silvestre Sampino,,
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, Adrian Mateusz Stankiewicz
Adrian Mateusz Stankiewicz,,
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, Federica Zacchini
Federica Zacchini,,
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, Joanna Gościk
Joanna Gościk,,
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, Agnieszka Szostak
Agnieszka Szostak,,
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, Artur Hugo Świergiel KFZiC
Artur Hugo Świergiel,,
- Department of Animal and Human Physiology
, Drago Gaspare
Drago Gaspare,,
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, Jacek Andrzej Modliński
Jacek Andrzej Modliński,,
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, Grażyna Ewa Ptak
Grażyna Ewa Ptak,,
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Journal seriesJournals of Gerontology Series A -Biological Sciences and Medical Sciences, ISSN 1079-5006
Issue year2017
Vol72
No11
Pages1465-1473
Publication size in sheets0.5
Keywords in English Delayed motherhood, maternal effects, brain disorder
DOIDOI:10.1093/gerona/glx016
URL https://academic.oup.com/biomedgerontology/article-pdf/doi/10.1093/gerona/glx016/17694865/glx016.pdf
Languageen angielski
LicenseOther; published final; Uznanie Autorstwa - Użycie Niekomercyjne - Bez utworów zależnych (CC-BY-NC-ND); with publication
Score (nominal)50
ScoreMinisterial score = 45.0, 20-12-2017, ArticleFromJournal
Ministerial score (2013-2016) = 50.0, 20-12-2017, ArticleFromJournal
Publication indicators WoS Impact Factor: 2016 = 5.957 (2) - 2016=5.783 (5)
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