Prospective evaluation of anxiety, depression and quality of life in medically inoperable early stage non-small cell lung cancer patients treated with stereotactic ablative radiotherapy

Jacek Rutkowski , Magdalena Szymanik , Maciej Blok , Joanna Kozaka , Renata Zaucha

Abstract

Aim: The aim of this prospective study was to evaluate the level of anxiety, depression, and quality of life (QoL) in medically inoperable patients with early stage non-small cell lung cancer (NSCLC) treated with stereotactic ablative radiotherapy (SABR).Background: Prolonged survival is equally important as maintaining high QoL and good psychological functioning during the treatment of lung cancer. Nowadays available SABR has markedly changed clinical care and outcomes in the group of medically inoperable patients. To our knowledge, analysis of QoL and psychological state has not been performed in Polish patients with early NSCLC treated with SABR.Materials and methods: Research group consisted of medically inoperable, early NSCLC (T1-2aN0M0) patients qualified to SABR. Patients were asked to complete Polish versions of the European Organization for Research and Treatment of Cancer Quality of Life- Core Questionnaire (EORTC QLQ-C30) with the Lung Cancer Questionnaire (LC13) and Hospital Anxiety and Depression Scale (HAD). These questionnaires were repeated 2 weeks and then 3 months after treatment completion.Results: We enrolled 51 patients who met the inclusion criteria. SABR did not deteriorate QoL and psychological functioning. On the contrary, clinically meaningful improvement was observed in emotional functioning, level of insomnia, anxiety and depression. Significantly worse improvement was shown in patients with chronic obstructive pulmonary disease (COPD).Conclusions: Our results confirm that SABR is well tolerated and does not have a deleterious effect on QoL and psychological state. Results of our study indicate the importance of additional psychological care in the group of patients with COPD. (C) 2017 Greater Poland Cancer Centre. Published by Elsevier Sp. z o.o. All rights reserved.
Author Jacek Rutkowski
Jacek Rutkowski,,
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, Magdalena Szymanik
Magdalena Szymanik,,
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, Maciej Blok
Maciej Blok,,
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, Joanna Kozaka (FSS / IPsych / DCPN)
Joanna Kozaka,,
- Division of Clinical Psychology and Neuropsychology
, Renata Zaucha
Renata Zaucha,,
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Other language title versions
Journal seriesReports of Practical Oncology and Radiotherapy, ISSN 1507-1367, e-ISSN 2083-4640, (B 12 pkt)
Issue year2017
Vol22
No3
Pages217-222
Publication size in sheets0.5
Keywords in Englishanxiety and depression, SABR, NSCLC, stereotactic radiotherapy, quality of life
DOIDOI:10.1016/j.rpor.2017.01.002
URL https://doi.org/10.1016/j.rpor.2017.01.002
Languagepl polski
Score (nominal)12
ScoreMinisterial score = 12.0, 15-12-2017, ArticleFromJournal
Ministerial score (2013-2016) = 12.0, 15-12-2017, ArticleFromJournal
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