Preferential uptake of polyunsaturated fatty acids by colorectal cancer cells
Adriana Mika , Jarosław Kobiela , Alicja Pakiet , Aleksandra Czumaj , Ewa Sokołowska , Wojciech Makarewicz , Michał Chmielewski , Piotr Stepnowski , Antonella Marino-Gammazza , Tomasz Śledziński
AbstractAlthough a growing body of evidence suggests that colorectal cancer (CRC) is associated with alterations of fatty acid (FA) profiles in serum and tumor tissues, available data about polyunsaturated fatty acid (PUFA) content in CRC patients are inconclusive. Our study showed that CRC tissues contained more PUFAs than normal large intestinal mucosa. However, serum levels of PUFAs in CRC patients were lower than in healthy controls. To explain the mechanism of PUFA alterations in CRC, we measured FA uptake by the colon cancer cells and normal colon cells. The levels of PUFAs in colon cancer cell culture medium decreased significantly with incubation time, while no changes were observed in the medium in which normal colon cells were incubated. Our findings suggest that the alterations in tumor and serum PUFA profiles result from preferential uptake of these FAs by cancer cells; indeed, PUFAs are essential for formation of cell membrane phospholipids during rapid proliferation of cancer cells. This observation puts into question potential benefits of PUFA supplementation in CRC patients.
|Journal series||Scientific Reports, ISSN 2045-2322, (N/A 140 pkt)|
|Publication size in sheets||0.5|
|License||Journal (articles only); published final; ; with publication|
|Score||= 140.0, 10-02-2020, ArticleFromJournal|
|Publication indicators||: 2016 = 1.401; : 2018 = 4.011 (2) - 2018=4.525 (5)|
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