Mutagenic activity of quaternary ammonium salt derivatives of carbohydrates

Barbara Dmochowska , Karol Sikora , Anna Woziwodzka , Jacek Piosik , Beata Podgórska

Abstract

This paper presents a study on a series of quaternary ammonium salt (QAS) derivatives of glucopyranosides with an elongated hydrophobic hydrocarbon chain. The new N-[6-(β-D-glucopyranosyloxy)hexyl]ammonium bromides and their O-acetyl derivatives were analyzed via 1H and 13C NMR spectroscopy. The mutagenic activity of the newly synthesized QAS was investigated using two different techniques: The Vibrio harveyi luminescence assay and the Ames test. The obtained results support previous findings contesting QAS safety and indicate that QAS, specifically pyridinium derivatives, might be mutagenic.
Author Barbara Dmochowska PChC
Barbara Dmochowska,,
- Laboratory of Carbohydrate Chemistry
, Karol Sikora PG - [Medical Uniwersity of Gdańsk (GUMed)]
Karol Sikora,,
- Laboratory of Glycochemistry
- Gdański Uniwersytet Medyczny
, Anna Woziwodzka KBMiK
Anna Woziwodzka,,
- Department of Molecular and Cellular Biology
, Jacek Piosik KBMiK
Jacek Piosik,,
- Department of Molecular and Cellular Biology
, Beata Podgórska KEM
Beata Podgórska,,
- Department of Molecular Evolution
Journal seriesBeilstein Journal of Organic Chemistry, ISSN 1860-5397
Issue year2016
Vol12
Pages1434-1439
Publication size in sheets0.5
Keywords in English6-bromohexyl D-glucopyranoside, microbiological mutagenicity test, quaternary ammonium salt
DOIDOI:10.3762/bjoc.12.138
URL http://www.beilstein-journals.org/bjoc/content/pdf/1860-5397-12-138.pdf
Languageen angielski
LicenseJournal (articles only); published final; Uznanie Autorstwa (CC-BY); with publication
Score (nominal)30
ScoreMinisterial score = 30.0, 20-12-2017, ArticleFromJournal
Ministerial score (2013-2016) = 30.0, 20-12-2017, ArticleFromJournal
Publication indicators WoS Impact Factor: 2016 = 2.337 (2) - 2016=2.705 (5)
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