Mutagenic activity of quaternary ammonium salt derivatives of carbohydrates
Barbara Dmochowska , Karol Sikora , Anna Woziwodzka , Jacek Piosik , Beata Podgórska
AbstractThis paper presents a study on a series of quaternary ammonium salt (QAS) derivatives of glucopyranosides with an elongated hydrophobic hydrocarbon chain. The new N-[6-(β-D-glucopyranosyloxy)hexyl]ammonium bromides and their O-acetyl derivatives were analyzed via 1H and 13C NMR spectroscopy. The mutagenic activity of the newly synthesized QAS was investigated using two different techniques: The Vibrio harveyi luminescence assay and the Ames test. The obtained results support previous findings contesting QAS safety and indicate that QAS, specifically pyridinium derivatives, might be mutagenic.
|Journal series||Beilstein Journal of Organic Chemistry, ISSN 1860-5397, (A 30 pkt)|
|Publication size in sheets||0.5|
|Keywords in English||6-bromohexyl D-glucopyranoside, microbiological mutagenicity test, quaternary ammonium salt|
|License||Journal (articles only); published final; ; with publication|
|Score|| = 30.0, 20-12-2017, ArticleFromJournal|
= 30.0, 20-12-2017, ArticleFromJournal
|Publication indicators||: 2016 = 2.337 (2) - 2016=2.705 (5)|
* presented citation count is obtained through Internet information analysis and it is close to the number calculated by the Publish or Perish system.