Antioxidant and cytoprotective activity of oxydiacetate complexes of cobalt(II) and nickel(II) with 1,10-phenantroline and 2,2'-bipyridine

Agnieszka Piotrowska-Kirschling , Joanna Drzeżdżon , Anna Kloska , Dariusz Wyrzykowski , Lech Chmurzyński , Dagmara Jacewicz

Abstract

The antioxidant properties of oxydiacetate complexes of cobalt(II) and nickel(II) with 1,10-phenantroline and 2,2′-bipyridine have been investigated towards the superoxide radical using the nitro blue tetrazolium chloride (NBT) test and the cyclic voltammetry (CV). Moreover, the biological activity of the complexes under study has been investigated in the Human Dermal Fibroblasts adult (HDFa) cell line. In the first step, the cytotoxic and the antiproliferative activities of the complexes were examined. Subsequently, the cytoprotective properties of the complexes have been investigated in an oxidative stress conditions induced by H2O2.
Publication typeIn press (online first, early view)
Author Agnieszka Piotrowska-Kirschling (FCh / DGICh / LPCC)
Agnieszka Piotrowska-Kirschling,,
- Laboratory of Physicochemistry of Coordination Complexes
, Joanna Drzeżdżon (FCh / DGICh / LPCC)
Joanna Drzeżdżon,,
- Laboratory of Physicochemistry of Coordination Complexes
, Anna Kloska (FB / DMBG)
Anna Kloska,,
- Katedra Biologii i Genetyki Medycznej
, Dariusz Wyrzykowski (FCh / DGICh / PBChN)
Dariusz Wyrzykowski,,
- Pracownia Biologicznej Chemii Nieorganicznej
, Lech Chmurzyński (FCh / DGICh / LPCC)
Lech Chmurzyński,,
- Laboratory of Physicochemistry of Coordination Complexes
, Dagmara Jacewicz (FCh / DGICh / LPCC)
Dagmara Jacewicz,,
- Laboratory of Physicochemistry of Coordination Complexes
Journal seriesBiological Trace Element Research, ISSN 0163-4984, (A 15 pkt)
Issue year2018
Noonline first
Pages1-8
Publication size in sheets0.5
Keywords in Englishcobalt(II) and nickel(II) complexes, cytoprotective activity, fibroblasts, oxydiacetate ion, oxidative stress
DOIDOI:10.1007/s12011-018-1243-z
URL https://link.springer.com/content/pdf/10.1007%2Fs12011-018-1243-z.pdf
Languageen angielski
Score (nominal)15
ScoreMinisterial score = 15.0, 15-06-2018, ArticleFromJournal
Ministerial score (2013-2016) = 15.0, 15-06-2018, ArticleFromJournal
Publication indicators WoS Impact Factor: 2016 = 2.399 (2) - 2016=2.059 (5)
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