Antioxidant and cytoprotective activity of oxydiacetate complexes of cobalt(II) and nickel(II) with 1,10-phenantroline and 2,2'-bipyridine
Agnieszka Piotrowska-Kirschling , Joanna Drzeżdżon , Anna Kloska , Dariusz Wyrzykowski , Lech Chmurzyński , Dagmara Jacewicz
AbstractThe antioxidant properties of oxydiacetate complexes of cobalt(II) and nickel(II) with 1,10-phenantroline and 2,2′-bipyridine have been investigated towards the superoxide radical using the nitro blue tetrazolium chloride (NBT) test and the cyclic voltammetry (CV). Moreover, the biological activity of the complexes under study has been investigated in the Human Dermal Fibroblasts adult (HDFa) cell line. In the first step, the cytotoxic and the antiproliferative activities of the complexes were examined. Subsequently, the cytoprotective properties of the complexes have been investigated in an oxidative stress conditions induced by H2O2.
|Journal series||Biological Trace Element Research, ISSN 0163-4984, (A 15 pkt)|
|Publication size in sheets||0.5|
|Keywords in English||cobalt(II) and nickel(II) complexes, cytoprotective activity, fibroblasts, oxydiacetate ion, oxidative stress|
|Score|| = 15.0, ArticleFromJournal|
= 15.0, ArticleFromJournal
|Publication indicators||: 2017 = 2.361 (2) - 2017=2.325 (5)|
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