Cytostatic drug removal using electrochemical oxidation with BDD electrode: degradation pathway and toxicity

Ewa Maria Siedlecka , Aleksandra Ofiarska , Agnieszka Fiszka-Borzyszkowska , Anna Białk-Bielińska , Piotr Stepnowski , Aleksandra Pieczyńska

Abstract

In the presented study, electrochemical oxidation of five anticancer drugs (5-fluorouracil (5-FU), ifosfamide (IF), cyclophosphamide (CF), methotrexate (MTX), imatinib (IMB)) using boron doped diamond (BDD) electrode was investigated. In the first step the operating parameters of electrolysis were optimized. Studies have demonstrated a significant influence of applying current density, temperature, pH of solution and initial concentration of 5-FU on the process efficiency. A comparison of the decomposition rate of all the tested drugs showed a decrease in the pseudo-first order rate constants in the following order: k(IMB) > k(MTX) > k(CF)zk(IF) > k(5-FU). Mineralization current efficiency (MCE) was determined for all the drugs based on the removal amount of total organic carbon (TOC) and their values decreased in the same order as values of drug degradation rate k. Based on the identified degradation products, electrochemical oxidation pathways of the decomposed drugs were proposed. In the case of CF, IF and 5-FU the degradation process occurred mainly through ketonization, hydroxylation and dehalogenation, while MTX and IMB were decomposed by attack of hydroxyl radicals on benzyl position in parent compounds. An important part of the research was the evaluation of eco-toxicity of electrochemically treated drug solutions against Lemna minor. Toxicity of initial 5-FU and MTX solutions towards L. minor were observed but after electrochemical treatment its toxicity decreased. The opposite trend was observed for CF and IF. In this case no significant toxicity was observed for the initial solutions of these drugs, while after electrochemical treatment an increase in growth inhibition of L. minor was found.
Author Ewa Maria Siedlecka (FCh / DET / LAOP)
Ewa Maria Siedlecka,,
- Laboratory of Advanced Oxidation Processes
, Aleksandra Ofiarska (FCh / DET / LAOP)
Aleksandra Ofiarska,,
- Laboratory of Advanced Oxidation Processes
, Agnieszka Fiszka-Borzyszkowska (FCh / DET / LAOP)
Agnieszka Fiszka-Borzyszkowska,,
- Laboratory of Advanced Oxidation Processes
, Anna Białk-Bielińska (FCh / DEA / LChER)
Anna Białk-Bielińska,,
- Laboratory of Chemical Environmental Risks
, Piotr Stepnowski (FCh / DEA / LChER)
Piotr Stepnowski,,
- Laboratory of Chemical Environmental Risks
, Aleksandra Pieczyńska (FCh / DET / LAOP)
Aleksandra Pieczyńska,,
- Laboratory of Advanced Oxidation Processes
Journal seriesWater Research, ISSN 0043-1354, (A 45 pkt)
Issue year2018
Vol144
Pages235-245
Publication size in sheets0.5
Keywords in Englishanticancer drug, electrochemical oxidation, degradation pathway, eco-toxicity
DOIDOI:10.1016/j.watres.2018.07.035
URL https://doi.org/10.1016/j.watres.2018.07.035
Languageen angielski
Score (nominal)45
ScoreMinisterial score = 45.0, 05-11-2018, ArticleFromJournal
Ministerial score (2013-2016) = 45.0, 05-11-2018, ArticleFromJournal
Publication indicators Scopus Citations = 0; WoS Impact Factor: 2016 = 6.942 (2) - 2016=7.715 (5)
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