Structure, physicochemical and biological properties of an aqua (2,2‘,2‘‘-Nitrilotriacetato)-oxidovanadium(IV) salt with 4-methylpyridinium cation

Aleksandra Tesmar , Dariusz Wyrzykowski , Katarzyna Kazimierczuk , Julia Kłak , Szymon Kowalski , Iwona Inkielewicz-Stępniak , Joanna Drzeżdżon , Dagmara Jacewicz , Lech Chmurzyński

Abstract

The crystal structure of a nitrilotriacetate (nta) oxidovanadium(IV) salt with 4-methylpyridinium cation, [4-Me(Py)H]+, of [4-Me(Py)H][VO(nta)(H2O)] stoichiometry was determined. The complex comprises a discrete mononuclear [VO(nta)(H2O)]– coordination entity that can be rarely found among other known compounds containing nitrilotriacetate oxidovanadium(IV) moieties. The complex was characterized by spectroscopic (IR and EPR) methods, magnetic measurements, and thermogravimetry (TG-FTIR). The stability of the title compound in aqueous solutions was investigated by using the potentiometric titration method. Furthermore, spectrophotometric (UV/Vis) studies have revealed that the compound is capable to scavenge the superoxide free radicals (O2•–) as well as stable organic radicals i.e. 2,2′-azinobis(3-ethylbenzothiazoline-6 sulfonic acid) cation radical (ABTS+•) and 2,2-diphenyl-1-picrylhydrazyl radical (DPPH•). Finally, biological properties of the complex studied were investigated in relation to its cytoprotective activity against the oxidative damage generated exogenously by using hydrogen peroxide in the HT22 hippocampal neuronal cell line (the MTT assay). Additionally, the biological action of the compound towards two human osteosarcoma HOS and MG-63 cell lines (the MTT and BrdU tests) as well as the untransformed human osteoblast hFOB 1.19 cell line was tested.
Author Aleksandra Tesmar (FCh / DGICh / LPCC)
Aleksandra Tesmar,,
- Laboratory of Physicochemistry of Coordination Complexes
, Dariusz Wyrzykowski (FCh / DGICh / PBChN)
Dariusz Wyrzykowski,,
- Pracownia Biologicznej Chemii Nieorganicznej
, Katarzyna Kazimierczuk
Katarzyna Kazimierczuk,,
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, Julia Kłak
Julia Kłak,,
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, Szymon Kowalski
Szymon Kowalski,,
-
, Iwona Inkielewicz-Stępniak
Iwona Inkielewicz-Stępniak,,
-
, Joanna Drzeżdżon (FCh / DGICh / LPCC)
Joanna Drzeżdżon,,
- Laboratory of Physicochemistry of Coordination Complexes
, Dagmara Jacewicz (FCh / DGICh / LPCC)
Dagmara Jacewicz,,
- Laboratory of Physicochemistry of Coordination Complexes
, Lech Chmurzyński (FCh / DGICh / LPCC)
Lech Chmurzyński,,
- Laboratory of Physicochemistry of Coordination Complexes
Journal seriesZeitschrift Fur Anorganische und Allgemeine Chemie, ISSN 0044-2313, (A 20 pkt)
Issue year2017
Vol643
No7
Pages501-510
Publication size in sheets0.5
DOIDOI:10.1002/zaac.201700022
URL http://onlinelibrary.wiley.com/doi/10.1002/zaac.201700022/epdf
Languageen angielski
Score (nominal)20
ScoreMinisterial score = 20.0, 20-12-2017, ArticleFromJournal
Ministerial score (2013-2016) = 20.0, 20-12-2017, ArticleFromJournal
Publication indicators WoS Impact Factor: 2016 = 1.144 (2) - 2016=1.043 (5)
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