Metody in-vivo badania właściwości antyoksydacyjnych związków kompleksowych

Jacek Malinowski , Joanna Drzeżdżon , Lech Chmurzyński , Dagmara Jacewicz

Abstract

This article describes the in-vivomethods of studying the antioxidant properties of complex compounds. The reduced glutathione (GSH) method, which uses the reactivity of the reduced form of GSH with free radicals, is among the described methods. Further the in-vivomethods are based on the use of antioxidant enzymes such as glutathione peroxidase, glutathione S-transferase, superoxide dismutase, catalase. These types of enzymes occur naturally in the human body and they are responsible for the inactivation of free radicals, e. g.superoxide dismutase catalyzes the reaction of disproportionation of superoxide anion radical to water and oxygen. The next in-vivomethods described in this article use γ-glutamyl transpeptidase and glutathione reductase, which are components of the antioxidant mechanism occurring in an organism. The last method described in this work relates to the lipid peroxidation, which is determined by the concentration of dimalonic aldehyde.
Author Jacek Malinowski (FCh / DGICh / LPCC)
Jacek Malinowski,,
- Laboratory of Physicochemistry of Coordination Complexes
, Joanna Drzeżdżon (FCh / DGICh / LPCC)
Joanna Drzeżdżon,,
- Laboratory of Physicochemistry of Coordination Complexes
, Lech Chmurzyński (FCh / DGICh / LPCC)
Lech Chmurzyński,,
- Laboratory of Physicochemistry of Coordination Complexes
, Dagmara Jacewicz (FCh / DGICh / LPCC)
Dagmara Jacewicz,,
- Laboratory of Physicochemistry of Coordination Complexes
Other language title versionsIn-vivo methods for testing of the antioxidant properties of complex compounds
Journal seriesWiadomości Chemiczne, ISSN 0043-5104, e-ISSN 2300-0295, (N/A 0 pkt)
Issue year2019
Vol73
No7-8
Pages523-538
Publication size in sheets0.75
Keywords in Polishwłaściwości przeciwutleniające, rodniki, metody in-vivo
Keywords in Englishantioxidant properties, radicals, in-vivo methods
URL https://ptchem.pl/storage/pages/July2019/zeszyt_7_8_2019.pdf
Languagepl polski
Score (nominal)5
Score sourcejournalList
ScoreMinisterial score = 5.0, 17-11-2019, ArticleFromJournal
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