Removal of cytostatic drugs by AOPs: a review of applied processes in the context of green technology

Aleksandra Pieczyńska , Agnieszka Fiszka-Borzyszkowska , Aleksandra Ofiarska , Ewa Maria Siedlecka


For decades, cytostatic drugs have been widely used in chemotherapy. However, many of these chemicals are classified as carcinogenic, mutagenic and teratogenic compounds, triggering widespread concerns about the drug-related occupational exposure and eco-toxicological risks to the environment. Moreover, cytostatics cannot be successfully removed from wastewater by conventional mechanical-biological wastewater treatment, which is due to the physicochemical properties of these drugs, e.g. low value of octanol-water partition coefficient (logKo/w), high solubility in water, low biodegradability, and sensitivity to photolysis. The present work is a review of data concerning the removal of cytostatic drugs by means of advanced oxidation processes (AOPs) that were reported in the period 2005–2016. Until now, AOPs-based methods for the cytostatic drug removal from water and wastewater, such as ozonation, UV/oxidant, UV/Fenton reaction, UV/photocatalyst, and electrochemical oxidation at active and non-active anodes, have been investigated. In this paper, we review the effectiveness of AOPs in the removal of cytostatic drugs from aqueous media. Moreover, we discuss the mechanisms of cytostatic drug decomposition based on the identified intermediates. The analysis of biodegradability and eco-toxicity of effluents after AOPs-based treatments is also presented.
Author Aleksandra Pieczyńska (FCh / DET / LAOP)
Aleksandra Pieczyńska,,
- Laboratory of Advanced Oxidation Processes
, Agnieszka Fiszka-Borzyszkowska (FCh / DET / LAOP)
Agnieszka Fiszka-Borzyszkowska,,
- Laboratory of Advanced Oxidation Processes
, Aleksandra Ofiarska (FCh / DET / LAOP)
Aleksandra Ofiarska,,
- Laboratory of Advanced Oxidation Processes
, Ewa Maria Siedlecka (FCh / DET / LAOP)
Ewa Maria Siedlecka,,
- Laboratory of Advanced Oxidation Processes
Journal seriesCritical Reviews in Environmental Science and Technology, ISSN 1064-3389, (A 40 pkt)
Issue year2017
Publication size in sheets3.2
Keywords in Englishcytostatic drugs, AOPs, treatment, intermediates, eco-toxicity
Languageen angielski
Score (nominal)40
ScoreMinisterial score = 40.0, 20-12-2017, ArticleFromJournal
Ministerial score (2013-2016) = 40.0, 20-12-2017, ArticleFromJournal
Publication indicators WoS Impact Factor: 2016 = 5.79 (2) - 2016=5.288 (5)
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* presented citation count is obtained through Internet information analysis and it is close to the number calculated by the Publish or Perish system.