N-alkyl derivatives of diosgenyl 2-amino-2-deoxy-β-D-glucopyranoside: synthesis and antimicrobial activity
Agata Walczewska , Daria Grzywacz , Dorota Bednarczyk , Małgorzata Dawgul , Andrzej Nowacki , Wojciech Kamysz , Beata Liberek , Henryk Myszka
AbstractDiosgenyl 2-amino-2-deoxy-β-D-glucopyranoside is a synthetic saponin exhibiting attractive pharmacological properties. Different pathways tested by us to obtain this glycoside are summarized here. Moreover, the synthesis of N-alkyl and N,N-dialkyl derivatives of the glucopyranoside is presented. Evaluation of antibacterial and antifungal activities of these derivatives indicates that they have no inhibitory activity against Gram-negative bacteria, whereas many of the tested N-alkyl saponins were found to inhibit the growth of Gram-positive bacteria and human pathogenic fungi.
|Journal series||Beilstein Journal of Organic Chemistry, ISSN 1860-5397, (A 30 pkt)|
|Publication size in sheets||0.5|
|License||Journal (articles only); published final; ; with publication|
|Score|| = 30.0, 22-05-2020, ArticleFromJournal|
= 30.0, 22-05-2020, ArticleFromJournal
|Publication indicators||= 7; = 8; : 2015 = 0.791; : 2015 = 2.697 (2) - 2015=2.844 (5)|
|Citation count*||12 (2020-05-24)|
* presented citation count is obtained through Internet information analysis and it is close to the number calculated by the Publish or Perish system.