Optical detection of ketoprofen by its electropolymerization on an indium tin oxide-coated optical fiber probe
Robert Bogdanowicz , Paweł Niedziałkowski , Michał Sobaszek , Dariusz Burnat , Wioleta Białobrzeska , Zofia Cebula , Petr Sezemsky , Marcin Koba , Vitezslav Stranak , Tadeusz Ossowski , Mateusz Śmietana
AbstractIn this work an application of optical fiber sensors for real-time optical monitoring of electrochemical deposition of ketoprofen during its anodic oxidation is discussed. The sensors were fabricated by reactive magnetron sputtering of indium tin oxide (ITO) on a 2.5 cm-long core of polymer-clad silica fibers. ITO tuned in optical properties and thickness allows for achieving a lossy-mode resonance (LMR) phenomenon and it can be simultaneously applied as an electrode in an electrochemical setup. The ITO-LMR electrode allows for optical monitoring of changes occurring at the electrode during electrochemical processing. The studies have shown that the ITO-LMR sensor’s spectral response strongly depends on electrochemical modification of its surface by ketoprofen. The effect can be applied for real-time detection of ketoprofen. The obtained sensitivities reached over 1400 nm/M (nm·mg(−1)·L) and 16,400 a.u./M (a.u.·mg(−1)·L) for resonance wavelength and transmission shifts, respectively. The proposed method is a valuable alternative for the analysis of ketoprofen within the concentration range of 0.25–250 μg mL(−1), and allows for its determination at therapeutic and toxic levels. The proposed novel sensing approach provides a promising strategy for both optical and electrochemical detection of electrochemical modifications of ITO or its surface by various compounds.
|Journal series||Sensors, ISSN 1424-8220|
|Publication size in sheets||0.7|
|Keywords in English||ketoprofen, anti-inflammatory drug, drug analysis, optical fiber sensor, reactive magnetron sputtering thin film, indium tin oxide (ITO), lossy-mode resonance (LMR), electrochemistry, electropolymerization|
|License||Journal (articles only); published final; ; with publication|
|Score|| = 30.0, 12-06-2018, ArticleFromJournal|
= 30.0, 12-06-2018, ArticleFromJournal
|Publication indicators||: 2016 = 2.677 (2) - 2016=2.964 (5)|
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