Optical detection of ketoprofen by its electropolymerization on an indium tin oxide-coated optical fiber probe

Robert Bogdanowicz , Paweł Niedziałkowski , Michał Sobaszek , Dariusz Burnat , Wioleta Białobrzeska , Zofia Cebula , Petr Sezemsky , Marcin Koba , Vitezslav Stranak , Tadeusz Ossowski , Mateusz Śmietana


In this work an application of optical fiber sensors for real-time optical monitoring of electrochemical deposition of ketoprofen during its anodic oxidation is discussed. The sensors were fabricated by reactive magnetron sputtering of indium tin oxide (ITO) on a 2.5 cm-long core of polymer-clad silica fibers. ITO tuned in optical properties and thickness allows for achieving a lossy-mode resonance (LMR) phenomenon and it can be simultaneously applied as an electrode in an electrochemical setup. The ITO-LMR electrode allows for optical monitoring of changes occurring at the electrode during electrochemical processing. The studies have shown that the ITO-LMR sensor’s spectral response strongly depends on electrochemical modification of its surface by ketoprofen. The effect can be applied for real-time detection of ketoprofen. The obtained sensitivities reached over 1400 nm/M (nm·mg(−1)·L) and 16,400 a.u./M (a.u.·mg(−1)·L) for resonance wavelength and transmission shifts, respectively. The proposed method is a valuable alternative for the analysis of ketoprofen within the concentration range of 0.25–250 μg mL(−1), and allows for its determination at therapeutic and toxic levels. The proposed novel sensing approach provides a promising strategy for both optical and electrochemical detection of electrochemical modifications of ITO or its surface by various compounds.
Author Robert Bogdanowicz
Robert Bogdanowicz,,
, Paweł Niedziałkowski (FCh / DACh / LSCh)
Paweł Niedziałkowski,,
- Laboratory of Supramolecular Chemistry
, Michał Sobaszek
Michał Sobaszek,,
, Dariusz Burnat
Dariusz Burnat,,
, Wioleta Białobrzeska (FCh / DACh / LSCh)
Wioleta Białobrzeska,,
- Laboratory of Supramolecular Chemistry
, Zofia Cebula (FCh / DACh / LSCh)
Zofia Cebula,,
- Laboratory of Supramolecular Chemistry
, Petr Sezemsky
Petr Sezemsky,,
, Marcin Koba
Marcin Koba,,
, Vitezslav Stranak
Vitezslav Stranak,,
, Tadeusz Ossowski (FCh / DACh / LSCh)
Tadeusz Ossowski,,
- Laboratory of Supramolecular Chemistry
et al.`
Journal seriesSensors, ISSN 1424-8220, (A 30 pkt)
Issue year2018
Publication size in sheets0.7
Keywords in English ketoprofen, anti-inflammatory drug, drug analysis, optical fiber sensor, reactive magnetron sputtering thin film, indium tin oxide (ITO), lossy-mode resonance (LMR), electrochemistry, electropolymerization
URL https://doi.org/10.3390/s18051361
Languageen angielski
LicenseJournal (articles only); published final; Uznanie Autorstwa (CC-BY); with publication
Score (nominal)30
ScoreMinisterial score = 30.0, ArticleFromJournal
Ministerial score (2013-2016) = 30.0, ArticleFromJournal
Publication indicators WoS Impact Factor: 2017 = 2.475 (2) - 2017=3.014 (5)
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* presented citation count is obtained through Internet information analysis and it is close to the number calculated by the Publish or Perish system.