Allosteric inhibition of Bcr-Abl kinase by high affinity monobody inhibitors directed to the Src homology 2 (SH2)-kinase interface

John Wojcik , Allan Joaquim Lamontanara , Grzegorz Grabe , Akiko Koide , Louesa Akin , Barbara Gerig , Oliver Hantschel , Shohei Koide

Abstract

n/a
Author John Wojcik
John Wojcik,,
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, Allan Joaquim Lamontanara
Allan Joaquim Lamontanara,,
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, Grzegorz Grabe MWB UG i GUMed
Grzegorz Grabe,,
- Intercollegiate Faculty of Biotechnology UG
, Akiko Koide
Akiko Koide,,
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, Louesa Akin
Louesa Akin,,
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, Barbara Gerig
Barbara Gerig,,
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, Oliver Hantschel
Oliver Hantschel,,
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, Shohei Koide
Shohei Koide,,
-
Journal seriesJournal of Biological Chemistry, ISSN 0021-9258
Issue year2016
Vol291
No16
Pages8836-8847
Keywords in EnglishABL tyrosine kinase, enzyme inhibitor, protein engineering, protein-protein interaction, Src homology 2 domain (SH2 domain), X-ray crystallography, FN3, PPI inhibitor
DOIDOI:10.1074/jbc.M115.707901
URL http://www.jbc.org/content/291/16/8836
Languageen angielski
LicenseJournal (articles only); published final; Uznanie Autorstwa (CC-BY); with publication
Score (nominal)35
ScoreMinisterial score = 35.0, 20-12-2017, ArticleFromJournal
Ministerial score (2013-2016) = 35.0, 20-12-2017, ArticleFromJournal
Publication indicators WoS Impact Factor: 2016 = 4.125 (2) - 2016=4.323 (5)
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