Determination of twenty pharmaceutical contaminants in soil using ultrasound-assisted extraction with gas chromatography-mass spectrometric detection

Jolanta Kumirska , Paulina Łukaszewicz , Magda Caban , Natalia Migowska , Alina Plenis , Anna Białk-Bielińska , Małgorzata Czerwicka , Fei Qi , Piotr Stepnowski

Abstract

In this paper, an analytical method for the simultaneous determination of twenty pharmaceuticals (eight non-steroidal anti-inflammatory drugs, five oestrogenic hormones, two antiepileptic drugs, two bblockers, and three antidepressants) in soils was developed. The optimal method included ultrasoundassisted extraction, a clean-up step on a silica gel column, derivatization using N,O-bis(trimethylsilyl) trifluoroacetamide (BSTFA) and 1% trimethylchlorosilane (TMCS) in pyridine and ethyl acetate (2:1:1, v/v/ v) for 30 min at 60°C, and determination by gas chromatography-mass spectrometry working in the selected ion monitoring mode. This affords good resolution, high sensitivity and reproducibility, and freedom from interferences even from complex matrices such as soils. The method detection limits ranged from 0.3 to 1.7 ng g-1, the intra-day precision represented as RSDs ranged from 1.1 to 10.0%, and the intra-day accuracy from 81.3 to 119.7%. The absolute recoveries of the target compounds were above 80%, except for valproic acid and diethylstilbestrol. The developed method was successfully applied in the analysis of the target compounds in soils collected in Poland. Among the 20 pharmaceuticals, 12 compounds were detected at least once in the soils. The determination of antiepileptic drugs, b-blockers, and antidepressants was also performed for the first time.
Author Jolanta Kumirska (FCh / DEA / LChAD)
Jolanta Kumirska,,
- Laboratory of Chemical Analytics and Diagnostics
, Paulina Łukaszewicz (FCh / DEA / LChER)
Paulina Łukaszewicz,,
- Laboratory of Chemical Environmental Risks
, Magda Caban (FCh / DEA / PAiMŚ)
Magda Caban,,
- Pracownia Analityki i Monitoringu Środowiska
, Natalia Migowska (FCh / DEA / LChER)
Natalia Migowska,,
- Laboratory of Chemical Environmental Risks
, Alina Plenis
Alina Plenis,,
-
, Anna Białk-Bielińska (FCh / DEA / LChER)
Anna Białk-Bielińska,,
- Laboratory of Chemical Environmental Risks
, Małgorzata Czerwicka (FCh / DBCh / LSB)
Małgorzata Czerwicka,,
- Laboratory of Structural Biochemistry
, Fei Qi
Fei Qi,,
-
, Piotr Stepnowski (FCh / DEA / LChER)
Piotr Stepnowski,,
- Laboratory of Chemical Environmental Risks
Journal seriesChemosphere, ISSN 0045-6535, (A 35 pkt)
Issue year2019
Vol232
Pages232-242
Publication size in sheets0.5
Keywords in EnglishAnalysis of pharmaceuticals in soil, pharmaceuticals in the environment, pharmaceuticals in soil, soil analysis, soil pollution
ASJC Classification2700 General Medicine; 1600 General Chemistry; 2304 Environmental Chemistry
DOIDOI:10.1016/j.chemosphere.2019.05.164
URL https://doi.org/10.1016/j.chemosphere.2019.05.164
Languageen angielski
Score (nominal)35
ScoreMinisterial score = 35.0, 24-07-2019, ArticleFromJournal
Publication indicators Scopus SNIP (Source Normalised Impact per Paper): 2016 = 1.606; WoS Impact Factor: 2017 = 4.427 (2) - 2017=4.551 (5)
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