Diosgenyl 2-amino-2-deoxy-β-D-galactopyranoside: synthesis, derivatives and antimicrobial activity
Henryk Myszka , Patrycja Sokołowska , Agnieszka Cieślińska , Andrzej Nowacki , Maciej Jaśkiewicz , Wojciech Kamysz , Beata Liberek
AbstractThe synthesis of diosgenyl 2-amino-2-deoxy-β-D-galactopyranoside is presented for the first time. This synthetic saponin was transformed into its hydrochloride as well as N-acyl, 2-ureido, N-alkyl, and N,N-dialkyl derivatives. Antifungal and antibacterial studies show that some of the obtained compounds are active against Gram-positive bacteria and Candida type fungi.
|Other language title versions|
|Journal series||Beilstein Journal of Organic Chemistry, ISSN 1860-5397|
|Publication size in sheets||0.3|
|Keywords in English||antimicrobial activities, D-galactosamine, diosgenin, glycosylation, saponin, tetrachlorophthalimido derivative|
|License||Journal (articles only); published final; ; with publication|
|Score|| = 30.0, 20-12-2017, ArticleFromJournal|
= 30.0, 20-12-2017, ArticleFromJournal
|Publication indicators||: 2016 = 2.337 (2) - 2016=2.705 (5)|
* presented citation count is obtained through Internet information analysis and it is close to the number calculated by the Publish or Perish system.