Small regulatory RNAs in lambdoid bacteriophages and phage-derived plasmids: not only antisense

Bożena Nejman-Faleńczyk , Sylwia Bloch , Katarzyna Licznerska , Agnieszka Felczykowska , Aleksandra Dydecka , Alicja Węgrzyn , Grzegorz Węgrzyn

Abstract

Until recently, only two small regulatory RNAs encoded by lambdoid bacteriophages were known. These transcripts are derived from paQ and pO promoters. The former one is supposed to act as an antisense RNA for expression of the Q gene, encoding a transcription antitermination protein. The latter transcript, called oop RNA, was initially proposed to have a double role, in establishing expression of the cI gene and in providing a primer for DNA replication. Although the initially proposed mechanisms by which oop RNA could influence the choice between two alternative developmental pathways of the phage and the initiation of phage DNA replication were found not true, the pO promoter has been demonstrated to be important for both regulation of phage development and control of DNA replication. Namely, the pO-derived transcript is an antisense RNA for expression of the cII gene, and pO is a part of a dual promoter system responsible for regulation of initiation of DNA synthesis from the oriλ region. Very recent studies identified a battery of small RNAs encoded by lambdoid bacteriophages existing as prophages in chromosomes of enterohemorrhagic Escherichia coli strains. Some of them have very interesting functions, like anti-small RNAs.
Author Bożena Nejman-Faleńczyk (FB / DMoB)
Bożena Nejman-Faleńczyk,,
- Department of Molecular Biology
, Sylwia Bloch (FB / DMoB)
Sylwia Bloch,,
- Department of Molecular Biology
, Katarzyna Licznerska (FB / DMoB)
Katarzyna Licznerska ,,
- Department of Molecular Biology
, Agnieszka Felczykowska (FB / DMoB)
Agnieszka Felczykowska,,
- Department of Molecular Biology
, Aleksandra Dydecka (FB / DMoB)
Aleksandra Dydecka ,,
- Department of Molecular Biology
, Alicja Węgrzyn
Alicja Węgrzyn,,
-
, Grzegorz Węgrzyn (FB / DMoB)
Grzegorz Węgrzyn,,
- Department of Molecular Biology
Journal seriesPlasmid, ISSN 0147-619X, (A 15 pkt)
Issue year2015
Vol78
Pages71-78
Publication size in sheets0.5
Keywords in Englishlambdoid bacteriophages, paQ promoter, pO promoter, oop RNA, DNA replication regulation, enterohemorrhagic Escherichia coli
DOIDOI:10.1016/j.plasmid.2014.07.006
URL http://dx.doi.org/10.1016/j.plasmid.2014.07.006
Languageen angielski
Score (nominal)20
ScoreMinisterial score = 15.0, 20-12-2017, ArticleFromJournal
Ministerial score (2013-2016) = 20.0, 20-12-2017, ArticleFromJournal
Publication indicators WoS Impact Factor: 2015 = 1.732 (2) - 2015=1.569 (5)
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