New N-substituted hydrazones, derivatives of uridyl aldehyde

Katarzyna Kral , Tadeusz Bieg , Agnieszka Kudelko , Anna Barabaś , Aleksandra Dąbrowska , Ilona Wandzik


N-substituted isomeric hydrazones of uridyl aldehyde have been synthesized. The occurrence of the dominant E isomers with respect to the azomethine group was confirmed by means of NMR spectroscopy. Synthesized hydrazones feature an acetonide moiety as a protection of two hydroxyl groups on the ribose part. The attempt to remove the protecting group resulted in an azo-hydrazone tautomeric mixture. The described compounds may be valuable chiral ligands for metal chelation. Assessment of manganese(II) ion affinity to one selected hydrazone was performed.
Author Katarzyna Kral
Katarzyna Kral,,
, Tadeusz Bieg
Tadeusz Bieg,,
, Agnieszka Kudelko
Agnieszka Kudelko,,
, Anna Barabaś (FCh / DGICh / LII)
Anna Barabaś,,
- Laboratory of Intermolecular Interactions
, Aleksandra Dąbrowska (FCh / DGICh / LII)
Aleksandra Dąbrowska,,
- Laboratory of Intermolecular Interactions
, Ilona Wandzik
Ilona Wandzik,,
Journal seriesNucleosides Nucleotides & Nucleic Acids [Nucleosides and Nucleotides], ISSN 1525-7770, [1532-2335], (A 15 pkt)
Issue year2017
Publication size in sheets0.5
Keywords in EnglishUridine, N-acyl hydrazone, chelate formation
ASJC Classification1311 Genetics; 1303 Biochemistry; 1313 Molecular Medicine; 2700 General Medicine
Languageen angielski
Score (nominal)15
ScoreMinisterial score = 15.0, 24-07-2019, ArticleFromJournal
Publication indicators WoS Citations = 0; Scopus SNIP (Source Normalised Impact per Paper): 2016 = 0.402; WoS Impact Factor: 2017 = 0.831 (2) - 2017=0.847 (5)
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