New N-substituted hydrazones, derivatives of uridyl aldehyde

Katarzyna Kral , Tadeusz Bieg , Agnieszka Kudelko , Anna Barabaś , Aleksandra Dąbrowska , Ilona Wandzik

Abstract

N-substituted isomeric hydrazones of uridyl aldehyde have been synthesized. The occurrence of the dominant E isomers with respect to the azomethine group was confirmed by means of NMR spectroscopy. Synthesized hydrazones feature an acetonide moiety as a protection of two hydroxyl groups on the ribose part. The attempt to remove the protecting group resulted in an azo-hydrazone tautomeric mixture. The described compounds may be valuable chiral ligands for metal chelation. Assessment of manganese(II) ion affinity to one selected hydrazone was performed.
Author Katarzyna Kral
Katarzyna Kral,,
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, Tadeusz Bieg
Tadeusz Bieg,,
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, Agnieszka Kudelko
Agnieszka Kudelko,,
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, Anna Barabaś (FCh / DGICh / LII)
Anna Barabaś,,
- Laboratory of Intermolecular Interactions
, Aleksandra Dąbrowska (FCh / DGICh / LII)
Aleksandra Dąbrowska,,
- Laboratory of Intermolecular Interactions
, Ilona Wandzik
Ilona Wandzik,,
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Journal seriesNucleosides Nucleotides & Nucleic Acids, ISSN 1525-7770 [1532-2335], (A 15 pkt)
Issue year2017
Vol36
No3
Pages159-169
Publication size in sheets0.5
Keywords in EnglishUridine, N-acyl hydrazone, chelate formation
DOIDOI:10.1080/15257770.2016.1231321
Languageen angielski
Score (nominal)15
ScoreMinisterial score = 15.0, 20-12-2017, ArticleFromJournal
Ministerial score (2013-2016) = 15.0, 20-12-2017, ArticleFromJournal
Publication indicators WoS Impact Factor: 2016 = 0.868 (2) - 2016=0.888 (5)
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