Dynamical landscape of heart rhythm in long-term heart transplant recipients: a way to discern erratic rhythms

Joanna Wdowczyk , Danuta Makowiec , Marcin Gruchała , Dorota Wejer , Zbigniew Struzik

Abstract

It is commonly believed that higher values of heart rate variability (HRV) indices account for better organization of the network of feedback reflexes driving an organism's response to actual bodily needs. In order to evaluate this organization in heart transplant (HTX) recipients, 58 nocturnal Holter signals of 14 HTX patients were analyzed. Their dynamical properties were evaluated by short-term HRV indices and measures grounded on entropy. Estimates grouped according to the patients' clinical progress: free of complications versus with complications, and arranged in order of the length of time since the HTX, lead us to the conclusion that higher HRV is associated with a worse outcome for HTX patients. Moreover, short-term HRV indices that are constant, rather than increasing over time, serve well in the prognosis of the future state of a HTX patient. These findings suggest that increases observed in HRV indices are related to erratic rhythms resulting from remodeling of the cardiac tissue (including heterogeneous innervation) in long-term HTX patients. Therefore, we hypothesize that dynamical landscape markers (entropy and fragmentation measures together with the short-term HRV indices) can serve as a tool in the exploration of the genesis of (non-respiratory sinus) arrhythmia.
Author Joanna Wdowczyk
Joanna Wdowczyk,,
-
, Danuta Makowiec (FMPI / ITPA)
Danuta Makowiec,,
- Institute of Theoretical Physics and Astrophysics
, Marcin Gruchała
Marcin Gruchała,,
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, Dorota Wejer (FMPI / IEP)
Dorota Wejer,,
- Institute of Experimental Physics
, Zbigniew Struzik
Zbigniew Struzik,,
-
Journal seriesFrontiers in Physiology, ISSN 1664-042X, (A 35 pkt)
Issue year2018
Vol9
Pages1-16
Publication size in sheets0.75
Keywords in Englishheart rate variability, entropic measures, heart transplant patients, erratic rhythm, heart rate fragmentation, autonomic nervous system
DOIDOI:10.3389/fphys.2018.00274
URL https://www.frontiersin.org/articles/10.3389/fphys.2018.00274/full
Languageen angielski
LicenseJournal (articles only); published final; Uznanie Autorstwa (CC-BY); with publication
Score (nominal)35
ScoreMinisterial score = 35.0, 25-10-2018, ArticleFromJournal
Ministerial score (2013-2016) = 35.0, 25-10-2018, ArticleFromJournal
Publication indicators WoS Impact Factor: 2016 = 4.134 (2) - 2016=4.187 (5)
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