Imaging of morphological background in selected functional and inflammatory gastrointestinal diseases in fMRI

Katarzyna Skrobisz , Grażyna Piotrowicz , Patrycja Naumczyk , Agnieszka Sabisz , Karolina Markiet , Grażyna Rydzewska , Edyta Szurowska

Abstract

The study focuses on evaluation of the Default Mode Network (DMN) activity in functional magnetic resonance imaging (fMRI) in resting state in patients with functional dyspepsia (FD) and irritable bowel syndrome (IBS), Crohn’s disease and colitis ulcerosa (IBD) in comparison to healthy volunteers. We assume that etiology of both functional and non-specific inflammatory bowel diseases is correlated with disrupted structure of axonal connections. We would like to identify the network of neuronal connections responsible for presentation of symptoms in these diseases. 56 patients (functional dyspepsia - 18, Crohn’s disease and colitis ulcerosa - 18,irritable bowel syndrome - 20) and 18 healthy volunteers underwent examination in MRI of the brain with assessment of brain morphology and central nervous system activity in functional imaging in resting state performed in 3T scanner. Compared to healthy controls’ DMN in patients with non-specific digestive tract diseases comprised additional areas in superior frontal gyrus of left hemisphere, in left cingulum and in the left supplementary motor area. Discovered differences in the DMNs can be interpreted as altered processing of homeostatic stimuli. Our study group involved patients suffering from both functional and non-specific inflammatory bowel diseases. Nevertheless a spectrum of changes in the study group (superior frontal gyrus of the left hemisphere, in the left cingulum and in the left supplementary motor area) we were able to find common features, differentiating the whole study group from the healthy controls.
Publication typeIn press (online first, early view)
Author Katarzyna Skrobisz
Katarzyna Skrobisz,,
-
, Grażyna Piotrowicz
Grażyna Piotrowicz,,
-
, Patrycja Naumczyk (FSS / IPsych / DGPsych)
Patrycja Naumczyk,,
- Division of General Psychology
, Agnieszka Sabisz
Agnieszka Sabisz,,
-
, Karolina Markiet
Karolina Markiet,,
-
, Grażyna Rydzewska
Grażyna Rydzewska,,
-
, Edyta Szurowska
Edyta Szurowska,,
-
Journal seriesFrontiers in Psychiatry, ISSN 1664-0640, (N/A 100 pkt)
Issue year2020
Noonline first
Pages1-1
Publication size in sheets0.3
Keywords in Englishfunctional magnetic resonance imaging (fMRI), Irritable bowel syndrome ( IBS), Inflammatory Bowel Diseases, Functional dyspepsia (fd), resting-state
ASJC Classification2738 Psychiatry and Mental health
DOIDOI:10.3389/fpsyt.2020.00461
Languageen angielski
Score (nominal)100
Score sourcejournalList
ScoreMinisterial score = 100.0, 14-05-2020, ArticleFromJournal
Publication indicators Scopus SNIP (Source Normalised Impact per Paper): 2018 = 0.991; WoS Impact Factor: 2018 = 3.161 (2)
Citation count*
Cite
Share Share

Get link to the record


* presented citation count is obtained through Internet information analysis and it is close to the number calculated by the Publish or Perish system.
Back
Confirmation
Are you sure?