Synthesis, structure, and biological activity of novel heterocyclic sulfonyl-carboximidamides
Katarzyna Gobis , Henryk Foks , Jarosław Sławiński , Artur Sikorski , Damian Trzybiński , Ewa Augustynowicz-Kopeć , Agnieszka Napiórkowska , Krzysztof Bojanowski
AbstractA series of novel heterocyclic sulfonyl-carboximidamides were synthesized in satisfactory yields via condensation of heterocyclic methyl carbimidates with 2-chlorobenzenesulfonamide and 4-chloropyridine-3-sulfonamide. New structures were confirmed by IR and NMR spectra as well as elemental analyses. X-ray crystallography of two derivatives was performed. The single-crystal structures confirmed the presence of a primary amine group in the amidine moiety. All the compounds were screened for their tuberculostatic, antibacterial, and anticancer activities. Preliminary results indicated that target compounds exhibited weak tuberculostatic and antibacterial activities. Seven compounds inhibited the growth of some cancer cell lines, whereas one of the 2-quinoline derivatives displayed favorable activity against all tested cancer cells with GI 50 values of 0.92–13 μM.
|Journal series||Monatshefte für Chemie, ISSN 0026-9247, e-ISSN 1434-4475, (A 20 pkt)|
|Publication size in sheets||0.55|
|License||Other; published final; ; with publication|
|Score|| = 25.0, 18-09-2018, ArticleFromJournal|
= 25.0, 18-09-2018, ArticleFromJournal
|Publication indicators||: 2013 = 1.347 (2) - 2013=1.445 (5)|
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