Antimicrobial, cytotoxic, and antioxidant activities and physicochemical characteristics of chromium(III) complexes with picolinate, dipicolinate, oxalate, 2,2′-bipyridine, and 4,4′-dimethoxy-2,2′-bipyridine as ligands in aqueous solutions

Joanna Drzeżdżon , Agnieszka Piotrowska-Kirschling , Jacek Malinowski , Anna Kloska , Barbara Gawdzik , Lech Chmurzyński , Dagmara Jacewicz

Abstract

The physicochemical properties of several chromium(III) complexes with ligands, such as picolinate, dipicolinate, oxalate, 2,2′-bipyridine, and 4,4′-dimethoxy-2,2′-bipyridine were investigated. First, the stability and formation constants of the synthesised chromium(III) complexes in aqueous solutions were evaluated with potentiometric titrations. In addition, the stoichiometry of each chromium(III) complex in water was analysed with conductometric titrations. Next, the potential antioxidant properties of chromium(III) compounds were determined by evaluating the ability of the synthesised complexes to reduce nitro blue tetrazolium salt. We also investigated the antimicrobial properties of the solutions of these compounds against Bacillus subtilis, Escherichia coli, Enterococcus faecalis, Pseudomonas aeruginosa, Staphylococcus aureus, and Staphylococcus epidermidis. The cytotoxic properties of chromium(III) complexes were tested using a human keratinocyte cell line (HaCaT).
Author Joanna Drzeżdżon (FCh / DGICh / LPCC)
Joanna Drzeżdżon,,
- Laboratory of Physicochemistry of Coordination Complexes
, Agnieszka Piotrowska-Kirschling (FCh / DGICh / LPCC)
Agnieszka Piotrowska-Kirschling,,
- Laboratory of Physicochemistry of Coordination Complexes
, Jacek Malinowski (FCh / DGICh / LPCC)
Jacek Malinowski,,
- Laboratory of Physicochemistry of Coordination Complexes
, Anna Kloska (FB / DMBG)
Anna Kloska,,
- Katedra Biologii i Genetyki Medycznej
, Barbara Gawdzik
Barbara Gawdzik,,
-
, Lech Chmurzyński (FCh / DGICh / LPCC)
Lech Chmurzyński,,
- Laboratory of Physicochemistry of Coordination Complexes
, Dagmara Jacewicz (FCh / DGICh / LPCC)
Dagmara Jacewicz,,
- Laboratory of Physicochemistry of Coordination Complexes
Journal seriesJournal of Molecular Liquids, ISSN 0167-7322, (A 30 pkt)
Issue year2019
Vol282
Pages441-447
Publication size in sheets0.5
Keywords in EnglishChromium(III) complexes, antibacterial activity, cytotoxicity, antioxidant properties
ASJC Classification2505 Materials Chemistry; 1606 Physical and Theoretical Chemistry; 1607 Spectroscopy; 3104 Condensed Matter Physics; 3107 Atomic and Molecular Physics, and Optics; 2504 Electronic, Optical and Magnetic Materials
DOIDOI:10.1016/j.molliq.2019.03.049
URL https://doi.org/10.1016/j.molliq.2019.03.049
Languageen angielski
Score (nominal)30
ScoreMinisterial score = 30.0, 24-07-2019, ArticleFromJournal
Publication indicators Scopus SNIP (Source Normalised Impact per Paper): 2016 = 1.212; WoS Impact Factor: 2017 = 4.513 (2) - 2017=3.929 (5)
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