Membrane partitioning of ionic liquid cations, anions and ion pairs - estimating the bioconcentration potential of organic ions

Joanna Dołżonek , Chul-woong Cho , Piotr Stepnowski , Marta Markiewicz , Jorg Thöming , Stefan Stolte

Abstract

Recent efforts have been directed towards better understanding the persistency and toxicity of ionic liquids (ILs) in the context of the “benign-by-design” approach, but the assessment of their bioaccumulation potential remains neglected. This paper reports the experimental membrane partitioning of IL cations (imidazolium, pyridinium, pyrrolidinium, phosphonium), anions ([C(CN)3]−, [B(CN)4]−, [FSO2)2N]−, [(C2F5)3PF3]−, [(CF3SO2)2N]−) and their combinations as a measure for estimating the bioconcentration factor (BCF). Both cations and anions can have a strong affinity for phosphatidylcholine bilayers, which is mainly driven by the hydrophobicity of the ions. This affinity is often reflected in the ecotoxicological impact. Our data revealed that the bioconcentration potential of IL cations and anions is much higher than expected from octanol-water-partitioning based estimations that have recently been presented. For some ILs, the membrane-water partition coefficient reached levels corresponding to BCFs that might become relevant in terms of the “B” (bioaccumulation potential) classification under REACH. However, this preliminary estimation need to be confirmed by in vivo bioconcentration studies.
Author Joanna Dołżonek (FCh / DEA / LChER)
Joanna Dołżonek,,
- Laboratory of Chemical Environmental Risks
, Chul-woong Cho - [Chonbuk National University]
Chul-woong Cho,,
-
- Chonbuk National University
, Piotr Stepnowski (FCh / DEA / LChER)
Piotr Stepnowski,,
- Laboratory of Chemical Environmental Risks
, Marta Markiewicz - [University of Bremen]
Marta Markiewicz,,
-
- University of Bremen
, Jorg Thöming - [University of Bremen]
Jorg Thöming,,
-
- University of Bremen
, Stefan Stolte (FCh / DEA / LChER)
Stefan Stolte,,
- Laboratory of Chemical Environmental Risks
Other language title versions
Journal seriesEnvironmental Pollution, ISSN 0269-7491, (A 40 pkt)
Issue year2017
Vol228
Pages378-389
Publication size in sheets0.55
Keywords in Englishbioaccumulation, lipid-water partitioning, PBT assessment, PFAS, QSAR
DOIDOI:10.1016/j.envpol.2017.04.079
URL https://doi.org/10.1016/j.envpol.2017.04.079
Languageen angielski
Score (nominal)40
ScoreMinisterial score = 40.0, 11-12-2018, ArticleFromJournal
Ministerial score (2013-2016) = 40.0, 11-12-2018, ArticleFromJournal
Publication indicators Scopus Citations = 4; WoS Citations = 3; WoS Impact Factor: 2016 = 5.099 (2) - 2016=5.552 (5)
Citation count*4 (2018-12-15)
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* presented citation count is obtained through Internet information analysis and it is close to the number calculated by the Publish or Perish system.
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