Vitamin D in autoimmune bullous disease
AbstractNumerous epidemiological studies have suggested a link between vitamin D deficiency and the development of various autoimmune diseases, including diabetes mellitus type 1, rheumatoid arthritis, inflammatory bowel disease, multiple sclerosis or systemic lupus erythematosus. More recently, such a link has been also proposed for autoimmune bullous diseases (AIBD). This is a relatively rare and potentially life-threatening, organ-specific group of inflammatory skin diseases characterized by the presence of tissue-bound and circulating autoantibodies against various molecules present in desmosomes (in pemphigus diseases) or hemidesmosomes (in pemphigoid diseases). In addition to the well-known role of vitamin D in calcium and phosphate homeostasis, the hormonally active vitamin D metabolite, 1,25-dihydroxyvitamin D3 (calcitriol), exerts potent effects on cellular differentiation and regulation of immune responses via binding to the vitamin D receptor present in most cells of the immune system. Since cells of both, the innate and adaptive immune systems, are known to be relevant in AIBD, the role of vitamin D analogues in the treatment of patients with these disorders deserves much attention. This mini-review summarizes recent epidemiological and experimental studies on vitamin D involvement in the autoimmune bullous diseases.
|Journal series||Acta Biochimica Polonica, ISSN 0001-527X, e-ISSN 1734-154X, (N/A 40 pkt)|
|Publication size in sheets||0.50|
|Keywords in English||calcitriol, 1,25(OH)2D3, vitamin D, 25(OH)D, autoimmune bullous diseases|
|License||Journal (articles only); published final; ; with publication|
|Score||= 40.0, 08-04-2020, ArticleFromJournal|
|Publication indicators||: 2018 = 0.640; : 2018 = 1.626 (2) - 2018=1.522 (5)|
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