Vitamin D in autoimmune bullous disease

Stefan Tukaj

Abstract

Numerous epidemiological studies have suggested a link between vitamin D deficiency and the development of various autoimmune diseases, including diabetes mellitus type 1, rheumatoid arthritis, inflammatory bowel disease, multiple sclerosis or systemic lupus erythematosus. More recently, such a link has been also proposed for autoimmune bullous diseases (AIBD). This is a relatively rare and potentially life-threatening, organ-specific group of inflammatory skin diseases characterized by the presence of tissue-bound and circulating autoantibodies against various molecules present in desmosomes (in pemphigus diseases) or hemidesmosomes (in pemphigoid diseases). In addition to the well-known role of vitamin D in calcium and phosphate homeostasis, the hormonally active vitamin D metabolite, 1,25-dihydroxyvitamin D3 (calcitriol), exerts potent effects on cellular differentiation and regulation of immune responses via binding to the vitamin D receptor present in most cells of the immune system. Since cells of both, the innate and adaptive immune systems, are known to be relevant in AIBD, the role of vitamin D analogues in the treatment of patients with these disorders deserves much attention. This mini-review summarizes recent epidemiological and experimental studies on vitamin D involvement in the autoimmune bullous diseases.
Author Stefan Tukaj (FB/DMoB)
Stefan Tukaj,,
- Department of Molecular Biology
Journal seriesActa Biochimica Polonica, ISSN 0001-527X, e-ISSN 1734-154X, (N/A 40 pkt)
Issue year2020
Vol67
No1
Pages1-5
Publication size in sheets0.50
Keywords in Englishcalcitriol, 1,25(OH)2D3, vitamin D, 25(OH)D, autoimmune bullous diseases
ASJC Classification1300 General Biochemistry, Genetics and Molecular Biology
DOIDOI:10.18388/abp.2020_2905
URL https://doi.org/10.18388/abp.2020_2905
Languageen angielski
LicenseJournal (articles only); published final; Uznanie Autorstwa - Na Tych Samych Warunkach (CC-BY-SA); with publication
Score (nominal)40
Score sourcejournalList
ScoreMinisterial score = 40.0, 08-04-2020, ArticleFromJournal
Publication indicators Scopus SNIP (Source Normalised Impact per Paper): 2018 = 0.640; WoS Impact Factor: 2018 = 1.626 (2) - 2018=1.522 (5)
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