Functionalized ACC molecule as an effective peptide clasp
Marcin Czapla , Sylwia Freza
AbstractUtilizing 1,2-diaminocyclopropane-1,2-dicarboxylic acid (DACDC) as a tetrafunctional peptide linker is proposed and discussed on the basis of the ab initio second-order Møller-Plesset and density functional theory (DFT) theoretical studies. It is demonstrated that the DACDC molecule may form four peptide bonds with natural amino acids such as alanine and, as a consequence, two peptide chains might be connected to each other by the DACDC unit which in turn reveals the ability of DACDC to act as a new type of peptide linker – peptide clasp.
|Journal series||Chemical Physics Letters, ISSN 0009-2614, (A 25 pkt)|
|Publication size in sheets||0.5|
|Keywords in English||ACC, DACDC, Peptide clasp, Peptide linker, Cross-linking|
|Score|| = 25.0, ArticleFromJournal|
= 30.0, ArticleFromJournal
|Publication indicators||: 2017 = 1.686 (2) - 2017=1.615 (5)|
* presented citation count is obtained through Internet information analysis and it is close to the number calculated by the Publish or Perish system.