Functionalized ACC molecule as an effective peptide clasp
Marcin Czapla , Sylwia Freza
AbstractUtilizing 1,2-diaminocyclopropane-1,2-dicarboxylic acid (DACDC) as a tetrafunctional peptide linker is proposed and discussed on the basis of the ab initio second-order Møller-Plesset and density functional theory (DFT) theoretical studies. It is demonstrated that the DACDC molecule may form four peptide bonds with natural amino acids such as alanine and, as a consequence, two peptide chains might be connected to each other by the DACDC unit which in turn reveals the ability of DACDC to act as a new type of peptide linker – peptide clasp.
|Journal series||Chemical Physics Letters, ISSN 0009-2614, (A 25 pkt)|
|Publication size in sheets||0.5|
|Keywords in English||ACC, DACDC, Peptide clasp, Peptide linker, Cross-linking|
|Score|| = 25.0, 29-06-2018, ArticleFromJournal|
= 30.0, 29-06-2018, ArticleFromJournal
|Publication indicators||: 2016 = 1.815 (2) - 2016=1.759 (5)|
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