Functionalized ACC molecule as an effective peptide clasp

Marcin Czapla , Sylwia Freza

Abstract

Utilizing 1,2-diaminocyclopropane-1,2-dicarboxylic acid (DACDC) as a tetrafunctional peptide linker is proposed and discussed on the basis of the ab initio second-order Møller-Plesset and density functional theory (DFT) theoretical studies. It is demonstrated that the DACDC molecule may form four peptide bonds with natural amino acids such as alanine and, as a consequence, two peptide chains might be connected to each other by the DACDC unit which in turn reveals the ability of DACDC to act as a new type of peptide linker – peptide clasp.
Author Marcin Czapla (FCh / DTCh / LQCh)
Marcin Czapla,,
- Laboratory of Quantum Chemistry
, Sylwia Freza (FCh / DTCh / LQCh)
Sylwia Freza,,
- Laboratory of Quantum Chemistry
Journal seriesChemical Physics Letters, ISSN 0009-2614, (A 25 pkt)
Issue year2018
Vol703
Pages52-55
Publication size in sheets0.5
Keywords in EnglishACC, DACDC, Peptide clasp, Peptide linker, Cross-linking
DOIDOI:10.1016/j.cplett.2018.05.027
URL https://doi.org/10.1016/j.cplett.2018.05.027
Languageen angielski
Score (nominal)30
ScoreMinisterial score = 25.0, 29-06-2018, ArticleFromJournal
Ministerial score (2013-2016) = 30.0, 29-06-2018, ArticleFromJournal
Publication indicators WoS Impact Factor: 2016 = 1.815 (2) - 2016=1.759 (5)
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