Functionalized ACC molecule as an effective peptide clasp

Marcin Czapla , Sylwia Freza


Utilizing 1,2-diaminocyclopropane-1,2-dicarboxylic acid (DACDC) as a tetrafunctional peptide linker is proposed and discussed on the basis of the ab initio second-order Møller-Plesset and density functional theory (DFT) theoretical studies. It is demonstrated that the DACDC molecule may form four peptide bonds with natural amino acids such as alanine and, as a consequence, two peptide chains might be connected to each other by the DACDC unit which in turn reveals the ability of DACDC to act as a new type of peptide linker – peptide clasp.
Author Marcin Czapla (FCh / DTCh / LQCh)
Marcin Czapla,,
- Laboratory of Quantum Chemistry
, Sylwia Freza (FCh / DTCh / LQCh)
Sylwia Freza,,
- Laboratory of Quantum Chemistry
Journal seriesChemical Physics Letters, ISSN 0009-2614, (A 30 pkt)
Issue year2018
Publication size in sheets0.5
Keywords in EnglishACC, DACDC, Peptide clasp, Peptide linker, Cross-linking
ASJC Classification1606 Physical and Theoretical Chemistry; 3100 General Physics and Astronomy
Languageen angielski
Score (nominal)30
Score sourcejournalList
ScoreMinisterial score = 30.0, 28-01-2020, ArticleFromJournal
Publication indicators WoS Citations = 0; Scopus SNIP (Source Normalised Impact per Paper): 2018 = 0.634; WoS Impact Factor: 2018 = 1.901 (2) - 2018=1.696 (5)
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