Neuropsychiatric symptoms and faster progression of cognitive impairments as predictors of risk of conversion of mild cognitive impairment to dementia

Mariola Bidzan , Leszek Bidzan , Iwona Bidzan-Bluma

Abstract

Introduction: The aim of this research, based on 7 years of observations, was to assess the relationship between the dynamics of changes in the realm of cognitive functions in the early stages of observations and the presence of neuropsychiatric symptoms as well as further progression ofcognitive function impairments in people diagnosed with mild cognitive impairment (MCI).Material and methods: One hundred and ninety three individuals were included in the study, all of whom referred themselves to the Mental Health Clinic and were diagnosed with MCI based on the criteria of the Working Group on MCI. It was assumed that these individuals would be subjected tosystematic psychiatric and neuropsychological observation until they were diagnosed with dementia. This report concerns a completed 7-year period of these observations. Participants were assessed based on the following scales: MMSE, NPI and GDS.Results: The obtained results indicate statistically significant differences between groups of subjects at the time of inclusion in the study, regarding the frequency of occurrence and severity of the following categories of impairments: thought impairments (p < 0.001), arousal/aggression (p < 0.001), depression/dysphoria (p < 0.001), disinhibition (p < 0.03), irritability/lability(p < 0.001), abnormal motor behaviors (p < 0.02), as well as sleep and night-time behavior disorders (p < 0.01) Moreover, individuals who developed dementia during observation exhibited greater progression in cognitive function impairment assessed with the MMSE scale in the first year ofobservation (p < 0.01).Conclusions: The accruing of cognitive function impairments and the presence of neuropsychiatric symptoms seem to be important risk factors for the development of dementia.
Author Mariola Bidzan (FSS / IPsych / DCPN)
Mariola Bidzan,,
- Division of Clinical Psychology and Neuropsychology
, Leszek Bidzan
Leszek Bidzan,,
-
, Iwona Bidzan-Bluma (FSS / IPsych)
Iwona Bidzan-Bluma,,
- Institute of Psychology
Journal seriesArchives of Medical Science, ISSN 1734-1922, (A 30 pkt)
Issue year2017
Vol13
No5
Pages1-10
Publication size in sheets0.5
Keywords in Englishdementia, neuropsychology, mild cognitive impairment, cognitive impairments, neuropsychiatry
DOIDOI:10.5114/aoms.2017.68943
URL https://www.termedia.pl/Journal/-19/pdf-30309-10?filename=neuropsychiatric.pdf
Languageen angielski
LicenseJournal (articles only); published final; Uznanie Autorstwa - Użycie Niekomercyjne - Na tych samych warunkach (CC-BY-NC-SA); with publication
Score (nominal)30
ScoreMinisterial score = 30.0, 20-12-2017, ArticleFromJournal
Ministerial score (2013-2016) = 30.0, 20-12-2017, ArticleFromJournal
Publication indicators WoS Impact Factor: 2016 = 1.969 (2) - 2016=1.904 (5)
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