The coordination abilities of three novel analogues of saliva peptides: the influence of structural modification on the copper binding

Aleksandra Kotynia , Edward Krzyżak , Elżbieta Kamysz , Małgorzata Sobocińska , Justyna Brasuń

Abstract

Three novel analogues of salivary peptides as sialorphin (QHNPR) and opiorphin (QRFSR) were synthesized by the solid-phase method. The sequences of these ligands were following: AHNPR, QANPR and QRFPR. The aim of our work was investigation in what way some structural modifications may impact on coordination abilities of studied peptides. In this work we presented the interaction of pentapeptides with copper(II) ions in wide range of pH. To determine the coordination model of ligands there were carried out several studies by spectroscopy (UV–Vis, CD) methods and potentiometric measurements.
Author Aleksandra Kotynia
Aleksandra Kotynia,,
-
, Edward Krzyżak
Edward Krzyżak,,
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, Elżbieta Kamysz PChMB
Elżbieta Kamysz,,
- Laboratory of Chemistry of Biological Macromolecules
, Małgorzata Sobocińska PChMB
Małgorzata Sobocińska,,
- Laboratory of Chemistry of Biological Macromolecules
, Justyna Brasuń
Justyna Brasuń,,
-
Journal seriesInternational Journal of Peptide Research and Therapeutics, ISSN 1573-3149
Issue year2017
Vol23
No4
Pages409-418
Publication size in sheets0.5
Keywords in Englishanalogues of salivary pentapeptides, stability constants of copper(II) complexes, peptide synthesis, UV-Vis and CD spectroscopy
DOIDOI:10.1007/s10989-016-9569-x
URL http://link.springer.com/content/pdf/10.1007%2Fs10989-016-9569-x.pdf
Languageen angielski
LicenseOther; published final; Uznanie Autorstwa (CC-BY); with publication
Score (nominal)15
ScoreMinisterial score = 15.0, 20-12-2017, ArticleFromJournal
Ministerial score (2013-2016) = 15.0, 20-12-2017, ArticleFromJournal
Publication indicators WoS Impact Factor: 2016 = 0.904 (2) - 2016=0.882 (5)
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