The coordination abilities of three novel analogues of saliva peptides: the influence of structural modification on the copper binding
Aleksandra Kotynia , Edward Krzyżak , Elżbieta Kamysz , Małgorzata Sobocińska , Justyna Brasuń
AbstractThree novel analogues of salivary peptides as sialorphin (QHNPR) and opiorphin (QRFSR) were synthesized by the solid-phase method. The sequences of these ligands were following: AHNPR, QANPR and QRFPR. The aim of our work was investigation in what way some structural modifications may impact on coordination abilities of studied peptides. In this work we presented the interaction of pentapeptides with copper(II) ions in wide range of pH. To determine the coordination model of ligands there were carried out several studies by spectroscopy (UV–Vis, CD) methods and potentiometric measurements.
|Journal series||International Journal of Peptide Research and Therapeutics, ISSN 1573-3149, (A 15 pkt)|
|Publication size in sheets||0.5|
|Keywords in English||analogues of salivary pentapeptides, stability constants of copper(II) complexes, peptide synthesis, UV-Vis and CD spectroscopy|
|License||Other; published final; ; with publication|
|Score|| = 15.0, 20-12-2017, ArticleFromJournal|
= 15.0, 20-12-2017, ArticleFromJournal
|Publication indicators||: 2016 = 0.904 (2) - 2016=0.882 (5)|
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