The coordination abilities of three novel analogues of saliva peptides: the influence of structural modification on the copper binding

Aleksandra Kotynia , Edward Krzyżak , Elżbieta Kamysz , Małgorzata Sobocińska , Justyna Brasuń


Three novel analogues of salivary peptides as sialorphin (QHNPR) and opiorphin (QRFSR) were synthesized by the solid-phase method. The sequences of these ligands were following: AHNPR, QANPR and QRFPR. The aim of our work was investigation in what way some structural modifications may impact on coordination abilities of studied peptides. In this work we presented the interaction of pentapeptides with copper(II) ions in wide range of pH. To determine the coordination model of ligands there were carried out several studies by spectroscopy (UV–Vis, CD) methods and potentiometric measurements.
Author Aleksandra Kotynia
Aleksandra Kotynia,,
, Edward Krzyżak
Edward Krzyżak,,
, Elżbieta Kamysz (FCh / DMBt / LChBM)
Elżbieta Kamysz,,
- Laboratory of Chemistry of Biological Macromolecules
, Małgorzata Sobocińska (FCh / DMBt / LChBM)
Małgorzata Sobocińska,,
- Laboratory of Chemistry of Biological Macromolecules
, Justyna Brasuń
Justyna Brasuń,,
Journal seriesInternational Journal of Peptide Research and Therapeutics, ISSN 1573-3149, (A 15 pkt)
Issue year2017
Publication size in sheets0.5
Keywords in Englishanalogues of salivary pentapeptides, stability constants of copper(II) complexes, peptide synthesis, UV-Vis and CD spectroscopy
Languageen angielski
LicenseOther; published final; Uznanie Autorstwa (CC-BY); with publication
Score (nominal)15
ScoreMinisterial score = 15.0, 20-12-2017, ArticleFromJournal
Ministerial score (2013-2016) = 15.0, 20-12-2017, ArticleFromJournal
Publication indicators WoS Impact Factor: 2016 = 0.904 (2) - 2016=0.882 (5)
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* presented citation count is obtained through Internet information analysis and it is close to the number calculated by the Publish or Perish system.