Aging and hypertension - independent or intertwined white matter impairing factors? Insights from the quantitative diffusion tensor imaging

Agnieszka Sabisz , Patrycja Naumczyk , Anna Marcinkowska , Beata Graff , Dariusz Gąsecki , Anna Glińska , Marta Witkowska , Anna Jankowska , Aleksandra Konarzewska , Jerzy Kwela , Krzysztof Jodzio , Edyta Szurowska , Krzysztof Narkiewicz

Abstract

Aging disrupts white matter integrity, and so does continuous elevated blood pressure that accompanies hypertension (HTN). Yet, our understanding of the interrelationship between these factors is still limited. The study aimed at evaluating patterns of changes in diffusion parameters (as assessed by quantitative diffusion fiber tracking - qDTI) following both aging, and hypertension, as well as the nature of their linkage. 146 participants took part in the study: the control group (N = 61) and the patients with hypertension (N = 85), and were divided into three age subgroups (25-47, 48-56, 57-71 years). qDTI was used to calculate the values of fractional anisotropy, mean, radial and axial diffusivity in 20 main tracts of the brain. The effects of factors (aging and hypertension) on diffusion parameters of tracts were tested with a two-way ANOVA. In the right hemisphere there was no clear effect of the HTN, nor an interaction between the factors, though some age-related effects were observed. Contrary, in the left hemisphere both aging and hypertension contributed to the white matter decline, following a functional pattern. In the projection pathways and the fornix, HTN and aging played part independent of each other, whereas in association fibers and the corpus callosum if the hypertension effect was significant, an interaction was observed. HTN patients manifested faster decline of diffusion parameters but also reached a plateau earlier, with highest between-group differences noted in the middle-aged subgroup. Healthy and hypertensive participants have different brain aging patterns. The HTN is associated with acceleration of white matter integrity decline, observed mainly in association fibers of the left hemisphere.
Author Agnieszka Sabisz
Agnieszka Sabisz,,
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, Patrycja Naumczyk (FSS / IPsych / DGPsych)
Patrycja Naumczyk,,
- Division of General Psychology
, Anna Marcinkowska
Anna Marcinkowska,,
-
, Beata Graff
Beata Graff,,
-
, Dariusz Gąsecki
Dariusz Gąsecki,,
-
, Anna Glińska
Anna Glińska,,
-
, Marta Witkowska (FSS / IPsych / DGPsych)
Marta Witkowska,,
- Division of General Psychology
, Anna Jankowska
Anna Jankowska,,
-
, Aleksandra Konarzewska
Aleksandra Konarzewska,,
-
, Jerzy Kwela (FMPI / IEP)
Jerzy Kwela,,
- Institute of Experimental Physics
et al.`
Journal seriesFrontiers in Aging Neuroscience, ISSN 1663-4365, (A 40 pkt)
Issue year2019
Vol11
Pages1-11
Publication size in sheets0.5
Keywords in EnglishDTI, aging, hypertension, quantitative fiber tracking, diffusion tensor imaging Frontiers in
ASJC Classification2805 Cognitive Neuroscience; 1302 Ageing
DOIDOI:10.3389/fnagi.2019.00035
URL https://www.frontiersin.org/articles/10.3389/fnagi.2019.00035/pdf
Languageen angielski
LicenseJournal (articles only); published final; Uznanie Autorstwa (CC-BY); with publication
Score (nominal)40
ScoreMinisterial score = 40.0, 24-07-2019, ArticleFromJournal
Publication indicators Scopus SNIP (Source Normalised Impact per Paper): 2016 = 1.177; WoS Impact Factor: 2017 = 3.582 (2) - 2017=4.55 (5)
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