Aging and hypertension - independent or intertwined white matter impairing factors? Insights from the quantitative diffusion tensor imaging
Agnieszka Sabisz , Patrycja Naumczyk , Anna Marcinkowska , Beata Graff , Dariusz Gąsecki , Anna Glińska , Marta Witkowska , Anna Jankowska , Aleksandra Konarzewska , Jerzy Kwela , Krzysztof Jodzio , Edyta Szurowska , Krzysztof Narkiewicz
AbstractAging disrupts white matter integrity, and so does continuous elevated blood pressure that accompanies hypertension (HTN). Yet, our understanding of the interrelationship between these factors is still limited. The study aimed at evaluating patterns of changes in diffusion parameters (as assessed by quantitative diffusion fiber tracking - qDTI) following both aging, and hypertension, as well as the nature of their linkage. 146 participants took part in the study: the control group (N = 61) and the patients with hypertension (N = 85), and were divided into three age subgroups (25-47, 48-56, 57-71 years). qDTI was used to calculate the values of fractional anisotropy, mean, radial and axial diffusivity in 20 main tracts of the brain. The effects of factors (aging and hypertension) on diffusion parameters of tracts were tested with a two-way ANOVA. In the right hemisphere there was no clear effect of the HTN, nor an interaction between the factors, though some age-related effects were observed. Contrary, in the left hemisphere both aging and hypertension contributed to the white matter decline, following a functional pattern. In the projection pathways and the fornix, HTN and aging played part independent of each other, whereas in association fibers and the corpus callosum if the hypertension effect was significant, an interaction was observed. HTN patients manifested faster decline of diffusion parameters but also reached a plateau earlier, with highest between-group differences noted in the middle-aged subgroup. Healthy and hypertensive participants have different brain aging patterns. The HTN is associated with acceleration of white matter integrity decline, observed mainly in association fibers of the left hemisphere.
|Journal series||Frontiers in Aging Neuroscience, ISSN 1663-4365, (N/A 100 pkt)|
|Publication size in sheets||0.5|
|Keywords in English||DTI, aging, hypertension, quantitative fiber tracking, diffusion tensor imaging Frontiers in|
|License||Journal (articles only); published final; ; with publication|
|Score||= 100.0, 17-11-2019, ArticleFromJournal|
|Publication indicators||: 2018 = 1.069; : 2018 = 3.633 (2) - 2018=4.492 (5)|
|Citation count*||1 (2020-01-15)|
* presented citation count is obtained through Internet information analysis and it is close to the number calculated by the Publish or Perish system.