The electrical stimulation of the bed nucleus of the stria terminalis causes oxidative stress in skeletal muscle of rats

Mateusz Jakub Karnia , Dorota Myślińska , Katarzyna Patrycja Dzik , Damian Józef Flis , Ziemowit Ciepielewski , Magdalena Podlacha , Jan Jacek Kaczor

Abstract

Recent studies indicate that activation of hypothalamus-pituitary-adrenocortical axis (HPA) plays the crucial role in stress response, while several lines of evidence mark the bed nucleus of the stria terminalis (BST) as a major mediator of the HPA axis responses to stress. The purpose of this study was to investigate the influence of the corticosterone flux induced by the electrical stimulation of BST on markers of free radical damage of lipids and proteins and antioxidant enzyme activity in skeletal muscle of rats. The male Wistar rats were used and assigned to one of three groups: sham-operated (SHM; n = 6), two-week (ST2; n = 6), and four-week stimulated (ST4; n = 5) groups. Blood, soleus, and extensor digitorum longus muscles were collected. The chronic, 4-week electrical stimulation of the BST evokes increased plasma corticosterone concentration, which resulted in oxidative stress in skeletal muscles. We found higher level of lipid peroxidation markers, lower level of protein oxidation marker, and elevated antioxidant enzyme activity in both muscles. Our findings have also potential implication showing that reaction to the long-term "psychological stress" may lead to free radical damage of muscle.
Author Mateusz Jakub Karnia
Mateusz Jakub Karnia,,
-
, Dorota Myślińska (FB / DAHP)
Dorota Myślińska,,
- Department of Animal and Human Physiology
, Katarzyna Patrycja Dzik
Katarzyna Patrycja Dzik,,
-
, Damian Józef Flis
Damian Józef Flis,,
-
, Ziemowit Ciepielewski (FB / DAHP)
Ziemowit Ciepielewski,,
- Department of Animal and Human Physiology
, Magdalena Podlacha (FB / DAHP)
Magdalena Podlacha,,
- Department of Animal and Human Physiology
, Jan Jacek Kaczor
Jan Jacek Kaczor,,
-
Journal seriesOxidative Medicine and Cellular Longevity, ISSN 1942-0900, (A 30 pkt)
Issue year2018
Vol2018
Pages1-11
Publication size in sheets0.5
Article number4671213
ASJC Classification2700 General Medicine; 1302 Ageing; 1303 Biochemistry; 1307 Cell Biology
DOIDOI:10.1155/2018/4671213
URL http://downloads.hindawi.com/journals/omcl/2018/4671213.pdf
Languageen angielski
LicenseJournal (articles only); published final; Uznanie Autorstwa (CC-BY); with publication
Score (nominal)30
Score sourcejournalList
ScoreMinisterial score = 30.0, 06-02-2020, ArticleFromJournal
Publication indicators WoS Citations = 1; Scopus SNIP (Source Normalised Impact per Paper): 2017 = 1.315; WoS Impact Factor: 2018 = 4.868 (2) - 2018=5.392 (5)
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