Of mice and men : olfactory neuroblastoma among animals and humans
Aleksandra Lubojemska , M. Borejko , P. Czapiewski , R. Dziadziuszko , W. Biernat
AbstractOlfactory neuroblastoma (ONB) is a rare tumour of nasal cavity and paranasal sinuses that arises from the olfactory neuroepithelium and has unpredictable clinical course. As the sense of smell is phylogenetically one of the first senses and olfactory neuroepithelium is evolutionary conserved with striking similarities among different species, we performed an extensive analysis of the literature in order to evaluate the similarities and differences between animals and humans on the clinical, morphological, immunohistochemical, ultrastructural and molecular level. Our analysis revealed that ONB was reported mainly in mammals and showed striking similarities to human ONB. These observations provide rationale for introduction of therapy modalities used in humans into the veterinary medicine. Animal models of neuroblastoma should be considered for the preclinical studies evaluating novel therapies for ONB.
|Journal series||Veterinary and Comparative Oncology, ISSN 1476-5810|
|Publication size in sheets||0.6|
|Keywords in English||cat, dog, domestic animals, olfactory epithelium, olfactory neuroblastoma|
|Score|| = 45.0, 20-12-2017, ArticleFromJournal|
= 45.0, 20-12-2017, ArticleFromJournal
|Publication indicators||: 2016 = 1.819 (2) - 2016=2.316 (5)|
* presented citation count is obtained through Internet information analysis and it is close to the number calculated by the Publish or Perish system.