MicroRNAs in regulation of triple-negative breast cancer progression

Dominika Piasecka , Marcin Braun , Radzislaw Kordek , Rafał Sądej , Hanna Romanska


Purpose: Dysregulation of miRNA profile has been associated with a broad spectrum of cellular processes underlying progression of various human malignancies. Increasing evidence suggests that specific microRNA clusters might be of clinical utility, especially in triple-negative breast carcinoma (TNBC), devoid of both predictive markers and potential therapeutic targets. Here we provide a comprehensive review of the existing data on microRNAs in TNBC, their molecular targets, a putative role in invasive progression with a particular emphasis on the epithelial-to-mesenchymal transition (EMT) and acquisition of stem-cell properties (CSC), regarded both as prerequisites for metastasis, and significance for therapy. Methods: PubMed and Medline databases were systematically searched for the relevant literature. 121 articles have been selected and thoroughly analysed. Results: Several miRNAs associated with EMT/CSC and invasion were identified as significantly (1) upregulated: miR-10b, miR-21, miR-29, miR-9, miR-221/222, miR-373 or (2) downregulated: miR-145, miR-199a-5p, miR-200 family, miR-203, miR-205 in TNBC. Dysregulation of miR-10b, miR-21, miR-29, miR-145, miR-200 family, miR-203, miR-221/222 was reported of prognostic value in TNBC patients. Conclusion: Available data suggest that specific microRNA clusters might play an important role in biology of TNBC, understanding of which should assist disease prognostication and therapy.
Author Dominika Piasecka
Dominika Piasecka,,
, Marcin Braun
Marcin Braun,,
, Radzislaw Kordek
Radzislaw Kordek,,
, Rafał Sądej (IFB / DMedB)
Rafał Sądej,,
- Department of Medical Biotechnology
, Hanna Romanska
Hanna Romanska,,
Journal seriesJournal of Cancer Research and Clinical Oncology, ISSN 0171-5216, (A 25 pkt)
Issue year2018
Publication size in sheets0.5
Keywords in Englishtriple-negative breast carcinoma, microRNA, EMT, CSC, invasion
ASJC Classification2700 General Medicine; 2730 Oncology; 1306 Cancer Research
URL https://doi.org/10.1007/s00432-018-2689-2
Languageen angielski
LicenseOther; published final; Uznanie Autorstwa (CC-BY); with publication
Score (nominal)25
Score sourcejournalList
ScoreMinisterial score = 25.0, 31-01-2020, ArticleFromJournal
Publication indicators Scopus SNIP (Source Normalised Impact per Paper): 2018 = 0.919; WoS Impact Factor: 2018 = 3.332 (2) - 2018=3.014 (5)
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