MicroRNAs in regulation of triple-negative breast cancer progression
Dominika Piasecka , Marcin Braun , Radzislaw Kordek , Rafał Sądej , Hanna Romanska
AbstractPurpose: Dysregulation of miRNA profile has been associated with a broad spectrum of cellular processes underlying progression of various human malignancies. Increasing evidence suggests that specific microRNA clusters might be of clinical utility, especially in triple-negative breast carcinoma (TNBC), devoid of both predictive markers and potential therapeutic targets. Here we provide a comprehensive review of the existing data on microRNAs in TNBC, their molecular targets, a putative role in invasive progression with a particular emphasis on the epithelial-to-mesenchymal transition (EMT) and acquisition of stem-cell properties (CSC), regarded both as prerequisites for metastasis, and significance for therapy. Methods: PubMed and Medline databases were systematically searched for the relevant literature. 121 articles have been selected and thoroughly analysed. Results: Several miRNAs associated with EMT/CSC and invasion were identified as significantly (1) upregulated: miR-10b, miR-21, miR-29, miR-9, miR-221/222, miR-373 or (2) downregulated: miR-145, miR-199a-5p, miR-200 family, miR-203, miR-205 in TNBC. Dysregulation of miR-10b, miR-21, miR-29, miR-145, miR-200 family, miR-203, miR-221/222 was reported of prognostic value in TNBC patients. Conclusion: Available data suggest that specific microRNA clusters might play an important role in biology of TNBC, understanding of which should assist disease prognostication and therapy.
|Journal series||Journal of Cancer Research and Clinical Oncology, ISSN 0171-5216, (A 25 pkt)|
|Publication size in sheets||0.5|
|Keywords in English||triple-negative breast carcinoma, microRNA, EMT, CSC, invasion|
|License||Other; published final; ; with publication|
|Score|| = 25.0, 06-11-2018, ArticleFromJournal|
= 25.0, 06-11-2018, ArticleFromJournal
|Publication indicators||: 2016 = 3.503 (2) - 2016=3.144 (5)|
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