A single point mutation in ricin A-chain increases toxin degradation and inhibits EDEM1-dependent ER retrotranslocation

Iwona Sokołowska , Sébastien Wälchli , Grzegorz Węgrzyn , Kirsten Sandvig , Monika Słomińska-Wojewódzka

Abstract

n/a
Author Iwona Sokołowska (FB / DM)
Iwona Sokołowska ,,
- Department of Microbiology
, Sébastien Wälchli
Sébastien Wälchli,,
-
, Grzegorz Węgrzyn (FB / DMoB)
Grzegorz Węgrzyn,,
- Department of Molecular Biology
, Kirsten Sandvig
Kirsten Sandvig,,
-
, Monika Słomińska-Wojewódzka (FB / DMBG)
Monika Słomińska-Wojewódzka,,
- Katedra Biologii i Genetyki Medycznej
Journal seriesBiochemical Journal, ISSN 0264-6021, (A 35 pkt)
Issue year2011
Vol436
No2
Pages371-385
Keywords in EnglishER degradation-enhancing α-mannosidase I-like protein 1 (EDEM1), endoplasmic reticulum (ER), endosomal-lysosomal degradation, P250A mutation, retrotranslocation, ricin A-chain (RTA)
DOIDOI:10.1042/BJ20101493
URL http://www.biochemj.org/bj/436/0371/4360371.pdf
Languageen angielski
Score (nominal)35
Publication indicators WoS Impact Factor: 2011 = 4.897 (2) - 2011=4.693 (5)
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