Models in the research process of psoriasis
Katarzyna Bocheńska , Elwira Smolińska , Marta Moskot , Joanna Jakóbkiewicz-Banecka , Magdalena Gabig-Cimińska
AbstractPsoriasis is an ancient, universal chronic skin disease with a significant geographical variability, with the lowest incidence rate at the equator, increasing towards the poles. Insights into the mechanisms responsible for psoriasis have generated an increasing number of druggable targets and molecular drugs. The development of relevant in vitro and in vivo models of psoriasis is now a priority and an important step towards its cure. In this review, we summarize the current cellular and animal systems suited to the study of psoriasis. We discuss the strengths and limitations of the various models and the lessons learned. We conclude that, so far, there is no one model that can meet all of the research needs. Therefore, the choice model system will depend on the questions being addressed.
|Journal series||International Journal of Molecular Sciences, ISSN 1661-6596, e-ISSN 1422-0067|
|Publication size in sheets||0.8|
|Keywords in English||psoriasis, disease models, pathomechanism, biomedical tools, drug-development|
|License||Journal (articles only); published final; ; with publication|
|Score|| = 30.0, 12-03-2018, ArticleFromJournal|
= 30.0, 12-03-2018, ArticleFromJournal
|Publication indicators||: 2016 = 3.226 (2) - 2016=3.482 (5)|
* presented citation count is obtained through Internet information analysis and it is close to the number calculated by the Publish or Perish system.