Models in the research process of psoriasis

Katarzyna Bocheńska , Elwira Smolińska , Marta Moskot , Joanna Jakóbkiewicz-Banecka , Magdalena Gabig-Cimińska

Abstract

Psoriasis is an ancient, universal chronic skin disease with a significant geographical variability, with the lowest incidence rate at the equator, increasing towards the poles. Insights into the mechanisms responsible for psoriasis have generated an increasing number of druggable targets and molecular drugs. The development of relevant in vitro and in vivo models of psoriasis is now a priority and an important step towards its cure. In this review, we summarize the current cellular and animal systems suited to the study of psoriasis. We discuss the strengths and limitations of the various models and the lessons learned. We conclude that, so far, there is no one model that can meet all of the research needs. Therefore, the choice model system will depend on the questions being addressed.
Author Katarzyna Bocheńska KBM
Katarzyna Bocheńska ,,
- Department of Molecular Biology
, Elwira Smolińska KBM - [Medical Uniwersity of Gdańsk (GUMed)]
Elwira Smolińska ,,
- Department of Molecular Biology
- Gdański Uniwersytet Medyczny
, Marta Moskot KBM - [Polish Academy of Science]
Marta Moskot,,
- Department of Molecular Biology
- Polska Akademia Nauk
, Joanna Jakóbkiewicz-Banecka KBM
Joanna Jakóbkiewicz-Banecka,,
- Department of Molecular Biology
, Magdalena Gabig-Cimińska
Magdalena Gabig-Cimińska,,
-
Journal seriesInternational Journal of Molecular Sciences, ISSN 1661-6596, e-ISSN 1422-0067
Issue year2017
Vol18
No12
Pages1-17
Publication size in sheets0.8
Keywords in Englishpsoriasis, disease models, pathomechanism, biomedical tools, drug-development
DOIDOI:10.3390/ijms18122514
URL www.mdpi.com/1422-0067/18/12/2514/pdf
Languageen angielski
LicenseJournal (articles only); published final; Uznanie Autorstwa (CC-BY); with publication
Score (nominal)30
ScoreMinisterial score = 30.0, 12-03-2018, ArticleFromJournal
Ministerial score (2013-2016) = 30.0, 12-03-2018, ArticleFromJournal
Publication indicators WoS Impact Factor: 2016 = 3.226 (2) - 2016=3.482 (5)
Citation count*0
Cite
Share Share



* presented citation count is obtained through Internet information analysis and it is close to the number calculated by the Publish or Perish system.
Back