Nitric oxide and its derivatives in the cancer battlefield
Anna Kamm , Paulina Przychodzen , Alicja Kuban-Jankowska , Dagmara Jacewicz , Aleksandra Dąbrowska , Stephan Nussberger , Michał Woźniak , Magdalena Gorska-Ponikowska
AbstractElevated levels of reactive nitrogen species, alteration in redox balance and deregulated redox signaling are common hallmarks of cancer progression and chemoresistance. However, depending on the cellular context, distinct reactive nitrogen species are also hypothesized to mediate cytotoxic activity and are thus used in anticancer therapies. We present here the dual face of nitric oxide and its derivatives in cancer biology. Main derivatives of nitric oxide, such as nitrogen dioxide and peroxynitrite cause cell death by inducing protein and lipid peroxidation and/or DNA damage. Moreover, they control the activity of important protein players within the pro- and anti-apoptotic signaling pathways. Thus, the control of intracellular reactive nitrogen species may become a sophisticated tool in anticancer strategies.
|Journal series||Nitric Oxide-Biology and Chemistry, [Nitric Oxide - Biology and Chemistry], ISSN 1089-8603, e-ISSN 1089-8611, (N/A 100 pkt)|
|Publication size in sheets||0.60|
|Keywords in English||nitric oxide, peroxynitrite, nitrogen dioxide, nitrate fatty acids, cancer|
|ASJC Classification||; ; ;|
|Score||= 100.0, 29-01-2020, ArticleFromJournal|
|Publication indicators||= 1.000; : 2016 = 1.047; : 2018 = 3.371 (2) - 2018=3.713 (5)|
|Citation count*||9 (2020-07-07)|
* presented citation count is obtained through Internet information analysis and it is close to the number calculated by the Publish or Perish system.