Nitric oxide and its derivatives in the cancer battlefield

Anna Kamm , Paulina Przychodzen , Alicja Kuban-Jankowska , Dagmara Jacewicz , Aleksandra Dąbrowska , Stephan Nussberger , Michał Woźniak , Magdalena Gorska-Ponikowska

Abstract

Elevated levels of reactive nitrogen species, alteration in redox balance and deregulated redox signaling are common hallmarks of cancer progression and chemoresistance. However, depending on the cellular context, distinct reactive nitrogen species are also hypothesized to mediate cytotoxic activity and are thus used in anticancer therapies. We present here the dual face of nitric oxide and its derivatives in cancer biology. Main derivatives of nitric oxide, such as nitrogen dioxide and peroxynitrite cause cell death by inducing protein and lipid peroxidation and/or DNA damage. Moreover, they control the activity of important protein players within the pro- and anti-apoptotic signaling pathways. Thus, the control of intracellular reactive nitrogen species may become a sophisticated tool in anticancer strategies.
Author Anna Kamm
Anna Kamm,,
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, Paulina Przychodzen
Paulina Przychodzen,,
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, Alicja Kuban-Jankowska
Alicja Kuban-Jankowska,,
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, Dagmara Jacewicz (FCh/DGICh/LPCC)
Dagmara Jacewicz,,
- Laboratory of Physicochemistry of Coordination Complexes
, Aleksandra Dąbrowska (FCh/KChBionieorg./LII)
Aleksandra Dąbrowska,,
- Laboratory of Intermolecular Interactions
, Stephan Nussberger
Stephan Nussberger,,
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, Michał Woźniak
Michał Woźniak,,
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, Magdalena Gorska-Ponikowska
Magdalena Gorska-Ponikowska,,
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Journal seriesNitric Oxide-Biology and Chemistry, [Nitric Oxide - Biology and Chemistry], ISSN 1089-8603, e-ISSN 1089-8611, (N/A 100 pkt)
Issue year2019
Vol93
Pages102-114
Publication size in sheets0.60
Keywords in Englishnitric oxide, peroxynitrite, nitrogen dioxide, nitrate fatty acids, cancer
ASJC Classification1303 Biochemistry; 1306 Cancer Research; 1308 Clinical Biochemistry; 1314 Physiology
DOIDOI:10.1016/j.niox.2019.09.005
URL https://doi.org/10.1016/j.niox.2019.09.005
Languageen angielski
Score (nominal)100
Score sourcejournalList
ScoreMinisterial score = 100.0, 29-01-2020, ArticleFromJournal
Publication indicators WoS Citations = 1.000; Scopus SNIP (Source Normalised Impact per Paper): 2016 = 1.047; WoS Impact Factor: 2018 = 3.371 (2) - 2018=3.713 (5)
Citation count*9 (2020-07-07)
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* presented citation count is obtained through Internet information analysis and it is close to the number calculated by the Publish or Perish system.
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