Role of Phe-D5 isotopically labeled analogues of bradykinin on elucidation of its adsorption mode on Ag, Au, and Cu electrodes. Surface-enhanced Raman spectroscopy studies

Edyta Proniewicz , Ilja Ignatjev , Gediminas Niaura , Dariusz Sobolewski , Adam Prahl , Leonard M. Proniewicz


Raman (RS), surface‐enhanced Raman scattering (SERS), electrochemistry, and isotopic effect methods were used to characterize selective adsorption of two isotopically labeled bradykinin analogues, [(Phe‐D5)5]BK and [(Phe‐D5)8]BK, a hormone which is known to be involved in small‐cell and non‐small‐cell lung carcinoma and prostate cancer. The investigated analogues contain Phe residue, at position 5 or 8 in the amino acid sequence, substituted by Phe‐D5 (five protons of L‐phenylalanine ring substituted by deuterium). [(Phe‐D5)5]BK and [(Phe‐D5)8]BK were immobilized onto electrochemically roughened Ag, Au, and Cu electrode surfaces under different applied electrode potentials (−1.000 V to 0.200 V) in an aqueous solution containing 0.01 M phosphate buffer (pH = 7.0) and 0.1 M Na2SO4. Based on the analyses of the spectral profiles in the 920 – 1050 cm−1 spectral range, specific conclusions were drawn with respect to the Phe⋅⋅⋅metal interactions and changes in the interaction that occurred when the adsorption conditions were varied.
Author Edyta Proniewicz
Edyta Proniewicz,,
, Ilja Ignatjev
Ilja Ignatjev,,
, Gediminas Niaura
Gediminas Niaura,,
, Dariusz Sobolewski (FCh / DOCh / LChB)
Dariusz Sobolewski,,
- Laboratory of Chemistry of Biopolymers
, Adam Prahl (FCh / DOCh / LChB)
Adam Prahl,,
- Laboratory of Chemistry of Biopolymers
, Leonard M. Proniewicz
Leonard M. Proniewicz,,
Journal seriesJournal of Raman Spectroscopy, ISSN 0377-0486, (A 30 pkt)
Issue year2013
Publication size in sheets0.5
Languageen angielski
Score (nominal)30
ScoreMinisterial score = 30.0, 03-12-2018, ArticleFromJournal
Ministerial score (2013-2016) = 30.0, 03-12-2018, ArticleFromJournal
Publication indicators WoS Impact Factor: 2013 = 2.519 (2) - 2013=2.425 (5)
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* presented citation count is obtained through Internet information analysis and it is close to the number calculated by the Publish or Perish system.