Role of Phe-D5 isotopically labeled analogues of bradykinin on elucidation of its adsorption mode on Ag, Au, and Cu electrodes. Surface-enhanced Raman spectroscopy studies
Edyta Proniewicz , Ilja Ignatjev , Gediminas Niaura , Dariusz Sobolewski , Adam Prahl , Leonard M. Proniewicz
AbstractRaman (RS), surface‐enhanced Raman scattering (SERS), electrochemistry, and isotopic effect methods were used to characterize selective adsorption of two isotopically labeled bradykinin analogues, [(Phe‐D5)5]BK and [(Phe‐D5)8]BK, a hormone which is known to be involved in small‐cell and non‐small‐cell lung carcinoma and prostate cancer. The investigated analogues contain Phe residue, at position 5 or 8 in the amino acid sequence, substituted by Phe‐D5 (five protons of L‐phenylalanine ring substituted by deuterium). [(Phe‐D5)5]BK and [(Phe‐D5)8]BK were immobilized onto electrochemically roughened Ag, Au, and Cu electrode surfaces under different applied electrode potentials (−1.000 V to 0.200 V) in an aqueous solution containing 0.01 M phosphate buffer (pH = 7.0) and 0.1 M Na2SO4. Based on the analyses of the spectral profiles in the 920 – 1050 cm−1 spectral range, specific conclusions were drawn with respect to the Phe⋅⋅⋅metal interactions and changes in the interaction that occurred when the adsorption conditions were varied.
|Journal series||Journal of Raman Spectroscopy, ISSN 0377-0486, (A 30 pkt)|
|Publication size in sheets||0.5|
|Score|| = 30.0, 03-12-2018, ArticleFromJournal|
= 30.0, 03-12-2018, ArticleFromJournal
|Publication indicators||: 2013 = 2.519 (2) - 2013=2.425 (5)|
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