Disruption of Ionic Interactions between the Nucleotide Binding Domain 1 (NBD1) and Middle (M) Domain in Hsp100 Disaggregase Unleashes Toxic Hyperactivity and Partial Independence from Hsp70

Natalia Lipińska , Szymon Ziętkiewicz , Alicja Sobczak , Agnieszka Jurczyk , Wojciech Potocki , Ewa Morawiec , Aleksandra Wawrzycka , Krzysztof Gumowski , Magdalena Ślusarz , Sylwia Rodziewicz-Motowidło , Elżbieta Chruściel , Krzysztof Liberek

Abstract

n/a
Author Natalia Lipińska (IFB)
Natalia Lipińska,,
- Intercollegiate Faculty of Biotechnology UG
, Szymon Ziętkiewicz (IFB / M020 / DMCB)
Szymon Ziętkiewicz,,
- Department of Molecular and Cellular Biology
, Alicja Sobczak (IFB)
Alicja Sobczak,,
- Intercollegiate Faculty of Biotechnology UG
, Agnieszka Jurczyk (IFB / M020 / DMCB)
Agnieszka Jurczyk,,
- Department of Molecular and Cellular Biology
, Wojciech Potocki (IFB)
Wojciech Potocki,,
- Intercollegiate Faculty of Biotechnology UG
, Ewa Morawiec (IFB)
Ewa Morawiec,,
- Intercollegiate Faculty of Biotechnology UG
, Aleksandra Wawrzycka (IFB)
Aleksandra Wawrzycka,,
- Intercollegiate Faculty of Biotechnology UG
, Krzysztof Gumowski (IFB)
Krzysztof Gumowski,,
- Intercollegiate Faculty of Biotechnology UG
, Magdalena Ślusarz (FCh / DTCh / LMM)
Magdalena Ślusarz,,
- Laboratory of Molecular Modeling
, Sylwia Rodziewicz-Motowidło (FCh / DBCh / LMCh)
Sylwia Rodziewicz-Motowidło,,
- Laboratory of Medical Chemistry
et al.`
Journal seriesJournal of Biological Chemistry, ISSN 0021-9258, (A 35 pkt)
Issue year2013
Vol288
No4
Pages2857-2869
Publication size in sheets0.6
DOIDOI:10.1074/jbc.M112.387589
URL http://www.jbc.org/content/early/2012/12/11/jbc.M112.387589.full.pdf
Languageen angielski
LicenseJournal (articles only); published final; Uznanie Autorstwa (CC-BY); with publication
Score (nominal)35
ScoreMinisterial score = 35.0, 17-09-2018, ArticleFromJournal
Ministerial score (2013-2016) = 35.0, 17-09-2018, ArticleFromJournal
Publication indicators WoS Impact Factor: 2013 = 4.6 (2) - 2013=4.863 (5)
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