Proteins, peptides and peptidomimetics as active agents in implant surface functionalization

Przemysław Jurczak , Julia Witkowska , Sylwia Rodziewicz-Motowidło , Sławomir Lach

Abstract

The recent impact of implants on improving the human life quality has been enormous. During the past two decades we witnessed major advancements in both material and structural development of implants. They were driven mainly by the increasing patients’ demand and the need to address the major issues that come along with the initially underestimated complexity of the bone-implant interface. While both, the materials and design of implants reached a certain, balanced state, recent years brought a shift in focus towards the bone-implant interface as the weakest link in the increasing implant long-term usability. As a result, several approaches were developed. They aimed at influencing and enhancing the implant osseointegration and its proper behavior when under load and stress. With this review, we would like to discuss the recent advancements in the field of implant surface modifications, emphasizing the importance of chemical methods, focusing on proteins, peptides and peptidomimetics as promising agents for titanium surface coatings.
Author Przemysław Jurczak (FCh / DBCh / LMCh)
Przemysław Jurczak,,
- Laboratory of Medical Chemistry
, Julia Witkowska (FCh / DBCh / LMCh)
Julia Witkowska,,
- Laboratory of Medical Chemistry
, Sylwia Rodziewicz-Motowidło (FCh / DBCh / LMCh)
Sylwia Rodziewicz-Motowidło,,
- Laboratory of Medical Chemistry
, Sławomir Lach (FCh / DBCh / LMCh)
Sławomir Lach,,
- Laboratory of Medical Chemistry
Journal seriesAdvances in Colloid and Interface Science, ISSN 0001-8686, e-ISSN 1873-3727, (N/A 200 pkt)
Issue year2020
Vol276
Pages1-21
Publication size in sheets1
Article number102083
Keywords in EnglishImplants, osteointegration, osseointegratio, proteins, peptides, peptidomimetic, surface functionalization
ASJC Classification1505 Colloid and Surface Chemistry; 1606 Physical and Theoretical Chemistry; 3110 Surfaces and Interfaces
DOIDOI:10.1016/j.cis.2019.102083
URL https://doi.org/10.1016/j.cis.2019.102083
Languageen angielski
Score (nominal)200
Score sourcejournalList
ScoreMinisterial score = 200.0, 28-01-2020, ArticleFromJournal
Publication indicators Scopus SNIP (Source Normalised Impact per Paper): 2018 = 2.603; WoS Impact Factor: 2018 = 8.243 (2) - 2018=9.259 (5)
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