Proteins, peptides and peptidomimetics as active agents in implant surface functionalization
Przemysław Jurczak , Julia Witkowska , Sylwia Rodziewicz-Motowidło , Sławomir Lach
AbstractThe recent impact of implants on improving the human life quality has been enormous. During the past two decades we witnessed major advancements in both material and structural development of implants. They were driven mainly by the increasing patients’ demand and the need to address the major issues that come along with the initially underestimated complexity of the bone-implant interface. While both, the materials and design of implants reached a certain, balanced state, recent years brought a shift in focus towards the bone-implant interface as the weakest link in the increasing implant long-term usability. As a result, several approaches were developed. They aimed at influencing and enhancing the implant osseointegration and its proper behavior when under load and stress. With this review, we would like to discuss the recent advancements in the field of implant surface modifications, emphasizing the importance of chemical methods, focusing on proteins, peptides and peptidomimetics as promising agents for titanium surface coatings.
|Journal series||Advances in Colloid and Interface Science, ISSN 0001-8686, e-ISSN 1873-3727, (N/A 200 pkt)|
|Publication size in sheets||1.00|
|Keywords in English||Implants, osteointegration, osseointegratio, proteins, peptides, peptidomimetic, surface functionalization|
|ASJC Classification||; ;|
|Score||= 200.0, 22-05-2020, ArticleFromJournal|
|Publication indicators||= 1.000; : 2018 = 2.603; : 2018 = 8.243 (2) - 2018=9.259 (5)|
|Citation count*||4 (2020-06-24)|
* presented citation count is obtained through Internet information analysis and it is close to the number calculated by the Publish or Perish system.