Compensatory functional reorganization may precede hypertension-relatedbrain damage andcognitive decline: a functionalmagnetic resonance imaging study

Patrycja Naumczyk , Agnieszka Sabisz , Marta Witkowska , Beata Graff , Krzysztof Jodzio , Dariusz Gąsecki , Edyta Szurowska , Krzysztof Narkiewicz

Abstract

Objectives: Our study aimed at exploring structural and functional differences in the brain during higher cognitive processing between middle-aged hypertensive patients and controls matched for sex, age and years of education.Methods: Two groups of 20 patients took part in MRI examinations. This article reports the results of functional MRI during a Stroop color interference task and structural evaluations based on a modified Fazekas scale.Results: No intergroup differences were found in regards to the severity of white matter lesions (Mann–Whitney U test = 150.5, P > 0.1), nor from the task performance in the scanner (t(35) = 0.2, P > 0.1). However, brain activation patterns between patients and controls varied. Hypertensive patients involved significantly more cerebral areas during the processing, regardless of the task difficulty. Differences were found in 26 diverse regions of both primary and associative cortices (with a peak voxel located in the cuneus, Z = 6.94, P < 0.05 family-wise error corrected at voxel level).Conclusion: Our findings provide an insight into the brain mechanisms related to essential hypertension and suggest a functional reorganization (neuroplasticity) early in the course of the disease.
Author Patrycja Naumczyk (FSS / IPsych / DGPsych)
Patrycja Naumczyk,,
- Division of General Psychology
, Agnieszka Sabisz (FMPI / IEP)
Agnieszka Sabisz ,,
- Institute of Experimental Physics
, Marta Witkowska (FSS / IPsych / DGPsych)
Marta Witkowska,,
- Division of General Psychology
, Beata Graff
Beata Graff,,
-
, Krzysztof Jodzio (FSS / IPsych / DGPsych)
Krzysztof Jodzio,,
- Division of General Psychology
, Dariusz Gąsecki
Dariusz Gąsecki,,
-
, Edyta Szurowska
Edyta Szurowska,,
-
, Krzysztof Narkiewicz
Krzysztof Narkiewicz,,
-
Other language title versions
Journal seriesJournal of Hypertension, ISSN 0263-6352, (A 35 pkt)
Issue year2017
Vol35
No6
Pages1252-1262
Publication size in sheets0.5
Keywords in Englishexecutive functions, functional MRI, hypertension, white matter lesions
DOIDOI:10.1097/HJH.0000000000001293
URL http://journals.lww.com/jhypertension/Citation/2017/06000/Compensatory_functional_reorganization_may_precede.18.aspx
Languageen angielski
LicenseJournal (articles only); published final; Uznanie Autorstwa - Użycie Niekomercyjne - Bez utworów zależnych (CC-BY-NC-ND); with publication
Score (nominal)40
ScoreMinisterial score = 35.0, 20-12-2017, ArticleFromJournal
Ministerial score (2013-2016) = 40.0, 20-12-2017, ArticleFromJournal
Publication indicators WoS Impact Factor: 2016 = 4.085 (2) - 2016=4.437 (5)
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