Compensatory functional reorganization may precede hypertension-relatedbrain damage andcognitive decline: a functionalmagnetic resonance imaging study
Patrycja Naumczyk , Agnieszka Sabisz , Marta Witkowska , Beata Graff , Krzysztof Jodzio , Dariusz Gąsecki , Edyta Szurowska , Krzysztof Narkiewicz
AbstractObjectives: Our study aimed at exploring structural and functional differences in the brain during higher cognitive processing between middle-aged hypertensive patients and controls matched for sex, age and years of education.Methods: Two groups of 20 patients took part in MRI examinations. This article reports the results of functional MRI during a Stroop color interference task and structural evaluations based on a modified Fazekas scale.Results: No intergroup differences were found in regards to the severity of white matter lesions (Mann–Whitney U test = 150.5, P > 0.1), nor from the task performance in the scanner (t(35) = 0.2, P > 0.1). However, brain activation patterns between patients and controls varied. Hypertensive patients involved significantly more cerebral areas during the processing, regardless of the task difficulty. Differences were found in 26 diverse regions of both primary and associative cortices (with a peak voxel located in the cuneus, Z = 6.94, P < 0.05 family-wise error corrected at voxel level).Conclusion: Our findings provide an insight into the brain mechanisms related to essential hypertension and suggest a functional reorganization (neuroplasticity) early in the course of the disease.
|Other language title versions|
|Journal series||Journal of Hypertension, ISSN 0263-6352, (A 35 pkt)|
|Publication size in sheets||0.5|
|Keywords in English||executive functions, functional MRI, hypertension, white matter lesions|
|License||Journal (articles only); published final; ; with publication|
|Score|| = 35.0, 20-12-2017, ArticleFromJournal|
= 40.0, 20-12-2017, ArticleFromJournal
|Publication indicators||: 2016 = 4.085 (2) - 2016=4.437 (5)|
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