Function, evolution, and structure of J-domain proteins

Harm H. Kampinga , Claes Andreasson , Alessandro Barducci , Michael E. Cheetham , Douglas Cyr , Cecilia Emanuelsson , Pierre Genevaux , Jason E. Gestwicki , Pierre Goloubinoff , Jaime Huerta-Cepas , Janine Kirstein , Krzysztof Liberek , Matthias P. Mayer , Kazuhiro Nagata , Nadinath B. Nillegoda , Pablo Pulido , Carlos Ramos , Paolo De los Rios , Sabine Rospert , Rina Rosenzweig , Chandan Sahi , Mikko Taipale , Bartłomiej Tomiczek , Ryo Ushioda , Jason C. Young , Richard Zimmermann , Alicja Zylicz , Maciej Zylicz , Elizabeth A. Craig , Jarosław Marszałek


Hsp70 chaperone systems are very versatile machines present in nearly all living organisms and in nearly all intracellular compartments. They function in many fundamental processes through their facilitation of protein (re)folding, trafficking, remodeling, disaggregation, and degradation. Hsp70 machines are regulated by co-chaperones. J-domain containing proteins (JDPs) are the largest family of Hsp70 co-chaperones and play a determining role functionally specifying and directing Hsp70 functions. Many features of JDPs are not understood; however, a number of JDP experts gathered at a recent CSSI-sponsored workshop in Gdansk (Poland) to discuss various aspects of J-domain protein function, evolution, and structure. In this report, we present the main findings and the consensus reached to help direct future developments in the field of Hsp70 research.
Author Harm H. Kampinga
Harm H. Kampinga,,
, Claes Andreasson
Claes Andreasson,,
, Alessandro Barducci
Alessandro Barducci,,
, Michael E. Cheetham
Michael E. Cheetham,,
, Douglas Cyr
Douglas Cyr,,
, Cecilia Emanuelsson
Cecilia Emanuelsson,,
, Pierre Genevaux
Pierre Genevaux,,
, Jason E. Gestwicki
Jason E. Gestwicki,,
, Pierre Goloubinoff
Pierre Goloubinoff,,
, Jaime Huerta-Cepas
Jaime Huerta-Cepas,,
et al.`
Journal seriesCell Stress & Chaperones, ISSN 1355-8145, (N/A 70 pkt)
Issue year2019
Publication size in sheets0.50
Keywords in EnglishHeat shock protein 70 (Hsp70), J-domain proteins (JDPs), 8-stranded β-sandwich domain (SBDβ)
ASJC Classification1307 Cell Biology; 1303 Biochemistry
Languageen angielski
Score (nominal)70
Score sourcejournalList
ScoreMinisterial score = 70.0, 28-01-2020, ArticleFromJournal
Publication indicators WoS Citations = 6.000; Scopus SNIP (Source Normalised Impact per Paper): 2018 = 0.888; WoS Impact Factor: 2018 = 2.903 (2) - 2018=2.944 (5)
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