Autophagy stimulation as a promising approach in treatment of neurodegenerative diseases

Karolina Pierzynowska , Lidia Gaffke , Zuzanna Cyske , Michał Puchalski , Estera Rintz , Michał Bartkowski , Marta Osiadły , Michał Pierzynowski , Jagoda Mantej , Ewa Piotrowska , Grzegorz Węgrzyn

Abstract

Autophagy is a process of degradation of macromolecules in the cytoplasm, particularly proteins of a long half-life, as well as whole organelles, in eukaryotic cells. Lysosomes play crucial roles during this degradation. Autophagy is a phylogenetically old, and evolutionarily conserved phenomenon which occurs in all eukaryotic cells. It can be found in yeast Saccharomyces cerevisiae, insect Drosophila melanogaster, and mammals, including humans. Its high importance for cell physiology has been recognized, and in fact, dysfunctions causing impaired autophagy are associated with many severe disorders, including cancer and metabolic brain diseases. The types and molecular mechanisms of autophagy have been reviewed recently by others, and in this paper they will be summarized only briefly. Regulatory networks controlling the autophagy process are usually described as negative regulations. In contrast, here, we focus on different ways by which autophagy can be stimulated. In fact, activation of this process by different factors or processes can be considered as a therapeutic strategy in metabolic neurodegenerative diseases. These aspects are reviewed and discussed in this article.
Author Karolina Pierzynowska (FB / DMoB)
Karolina Pierzynowska,,
- Department of Molecular Biology
, Lidia Gaffke (FB / DMoB)
Lidia Gaffke,,
- Department of Molecular Biology
, Zuzanna Cyske (FB)
Zuzanna Cyske,,
- Faculty of Biology
, Michał Puchalski (FB)
Michał Puchalski,,
- Faculty of Biology
, Estera Rintz (FB)
Estera Rintz,,
- Faculty of Biology
, Michał Bartkowski (FB)
Michał Bartkowski,,
- Faculty of Biology
, Marta Osiadły (FB)
Marta Osiadły,,
- Faculty of Biology
, Michał Pierzynowski (FB)
Michał Pierzynowski,,
- Faculty of Biology
, Jagoda Mantej (FB)
Jagoda Mantej,,
- Faculty of Biology
, Ewa Piotrowska (FB / DMoB)
Ewa Piotrowska,,
- Department of Molecular Biology
et al.`
Journal seriesMetabolic Brain Disease, ISSN 0885-7490, (A 20 pkt)
Issue year2018
Vol33
No4
Pages989-1008
Publication size in sheets0.95
Keywords in Englishautophagy stimulation, lysosomes, therapeutic strategies, neurodegenerative diseases
DOIDOI:10.1007/s11011-018-0214-6
URL https://link.springer.com/content/pdf/10.1007%2Fs11011-018-0214-6.pdf
Languageen angielski
LicenseOther; published final; Uznanie Autorstwa (CC-BY); with publication
Score (nominal)25
ScoreMinisterial score = 20.0, 04-11-2018, ArticleFromJournal
Ministerial score (2013-2016) = 25.0, 04-11-2018, ArticleFromJournal
Publication indicators WoS Impact Factor: 2016 = 2.297 (2) - 2016=2.397 (5)
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