Autophagy stimulation as a promising approach in treatment of neurodegenerative diseases
Karolina Pierzynowska , Lidia Gaffke , Zuzanna Cyske , Michał Puchalski , Estera Rintz , Michał Bartkowski , Marta Osiadły , Michał Pierzynowski , Jagoda Mantej , Ewa Piotrowska , Grzegorz Węgrzyn
AbstractAutophagy is a process of degradation of macromolecules in the cytoplasm, particularly proteins of a long half-life, as well as whole organelles, in eukaryotic cells. Lysosomes play crucial roles during this degradation. Autophagy is a phylogenetically old, and evolutionarily conserved phenomenon which occurs in all eukaryotic cells. It can be found in yeast Saccharomyces cerevisiae, insect Drosophila melanogaster, and mammals, including humans. Its high importance for cell physiology has been recognized, and in fact, dysfunctions causing impaired autophagy are associated with many severe disorders, including cancer and metabolic brain diseases. The types and molecular mechanisms of autophagy have been reviewed recently by others, and in this paper they will be summarized only briefly. Regulatory networks controlling the autophagy process are usually described as negative regulations. In contrast, here, we focus on different ways by which autophagy can be stimulated. In fact, activation of this process by different factors or processes can be considered as a therapeutic strategy in metabolic neurodegenerative diseases. These aspects are reviewed and discussed in this article.
|Journal series||Metabolic Brain Disease, ISSN 0885-7490, (A 20 pkt)|
|Publication size in sheets||0.95|
|Keywords in English||autophagy stimulation, lysosomes, therapeutic strategies, neurodegenerative diseases|
|License||Other; published final; ; with publication|
|Score|| = 20.0, ArticleFromJournal|
= 25.0, ArticleFromJournal
|Publication indicators||= 4; = 2; : 2017 = 2.441 (2) - 2017=2.481 (5)|
|Citation count*||13 (2019-04-18)|
* presented citation count is obtained through Internet information analysis and it is close to the number calculated by the Publish or Perish system.