Differential effects of various soy isoflavone dietary supplements (nutraceuticals) on bacterial growth and human fibroblast viability

Karolina Pierzynowska , Agata Rzeszótko , Aleksandra Blendowska , Ewa Wieczerzak , Sylwia Rodziewicz-Motowidło , Ewa Piotrowska , Grzegorz Węgrzyn

Abstract

Flavonoids, polyphenolic compounds present in many food products, affect growth of different bacterial species when tested as purified or synthetic substances. They can also influence gene expression in human cells, like fibroblasts. Here, we asked if soy isoflavone extracts, commonly used in many products sold as anti- menopausal dietary supplements, influence bacterial growth similarly to a synthetic isoflavone, genistein. Four commercially available products were tested in amounts corresponding to genistein concentrations causing inhibition of growth of Vibrio harveyi (a model bacterium sensitive to this isoflavone) and Escherichia coli (a model bacterium resistant to genistein). Differential effects of various extracts on V. harveyi and E. coli growth, from stimulation, to no changes, to inhibition, were observed. Moreover, contrary to genistein, the tested extracts caused a decrease (to different extent) in viability of human dermal fibroblasts. These results indicate that effects of various soy isoflavone extracts on bacterial growth and viability of human cells are different, despite similar declared composition of the commercially available products.
Author Karolina Pierzynowska (FB / DMoB)
Karolina Pierzynowska,,
- Department of Molecular Biology
, Agata Rzeszótko (FB / DMoB)
Agata Rzeszótko,,
- Department of Molecular Biology
, Aleksandra Blendowska (FB)
Aleksandra Blendowska,,
- Faculty of Biology
, Ewa Wieczerzak (FCh / DBCh / LMCh)
Ewa Wieczerzak,,
- Laboratory of Medical Chemistry
, Sylwia Rodziewicz-Motowidło (FCh / DBCh / LMCh)
Sylwia Rodziewicz-Motowidło,,
- Laboratory of Medical Chemistry
, Ewa Piotrowska (FB / DMoB)
Ewa Piotrowska,,
- Department of Molecular Biology
, Grzegorz Węgrzyn (FB / DMoB)
Grzegorz Węgrzyn,,
- Department of Molecular Biology
Journal seriesActa Biochimica Polonica, ISSN 0001-527X, e-ISSN 1734-154X, (A 15 pkt)
Issue year2018
Vol64
No4
Pages325-332
Publication size in sheets0.5
Keywords in English genistein, soy isoflavone extracts, anti-menopausal dietary supplements, bacterial growth, viability of human cell
DOIDOI:10.18388/abp.2018_2596
URL https://doi.org/10.18388/abp.2018_2596
Languageen angielski
LicenseJournal (articles only); published final; Other open licence; with publication
Score (nominal)15
Publication indicators WoS Impact Factor: 2016 = 1.159 (2) - 2016=1.491 (5)
Citation count*
Cite
Share Share

Get link to the record


* presented citation count is obtained through Internet information analysis and it is close to the number calculated by the Publish or Perish system.
Back