Antibacterial peptides in dermatology - strategies for evaluation of allergic potential

Milena Deptuła , Anna Wardowska , Maria Dzierżyńska , Sylwia Rodziewicz-Motowidło , Michał Pikuła


During recent decades, the market for peptide-based drugs, including antimicrobial peptides, has vastly extended and evolved. These drugs can be useful in treatment of various types of disorders, e.g., cancer, autoimmune diseases, infections, and non-healing wounds. Although peptides are less immunogenic than other biologic therapeutics, they can still induce immune responses and cause allergies. It is important to evaluate the immunogenic and allergic potential of peptides before they are forwarded to the expensive stages of clinical trials. The process of the evaluation of immunogenicity and cytotoxicity is complicated, as in vitro models and bioinformatics tools cannot fully simulate situations in the clinic. Nevertheless, several potentially promising tests for the preclinical evaluation of peptide drugs have been implemented (e.g., cytotoxicity assays, the basophil activation test, and lymphocyte activation assays). In this review, we focus on strategies for evaluation of the allergic potential of peptide-based therapeutics.
Author Milena Deptuła - [Gdanski Uniwersytet Medyczny]
Milena Deptuła,,
- Gdanski Uniwersytet Medyczny
, Anna Wardowska - [Gdanski Uniwersytet Medyczny]
Anna Wardowska,,
- Gdanski Uniwersytet Medyczny
, Maria Dzierżyńska (FCh / DBCh / LMCh)
Maria Dzierżyńska,,
- Laboratory of Medical Chemistry
, Sylwia Rodziewicz-Motowidło (FCh / DBCh / LMCh)
Sylwia Rodziewicz-Motowidło,,
- Laboratory of Medical Chemistry
, Michał Pikuła - [Gdanski Uniwersytet Medyczny]
Michał Pikuła,,
- Gdanski Uniwersytet Medyczny
Journal seriesMolecules, ISSN , e-ISSN 1420-3049, (A 30 pkt)
Issue year2018
ASJC Classification1605 Organic Chemistry
Languageen angielski
LicenseJournal (articles only); published final; Uznanie Autorstwa (CC-BY); with publication
Score (nominal)30
ScoreMinisterial score = 30.0, 17-03-2019, ArticleFromJournal
Ministerial score (2013-2016) = 30.0, 17-03-2019, ArticleFromJournal
Publication indicators WoS Citations = 1; Scopus Citations = 1; Scopus SNIP (Source Normalised Impact per Paper): 2017 = 1.146; WoS Impact Factor: 2017 = 3.098 (2) - 2017=3.268 (5)
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* presented citation count is obtained through Internet information analysis and it is close to the number calculated by the Publish or Perish system.