Antibacterial peptides in dermatology - strategies for evaluation of allergic potential

Milena Deptuła , Anna Wardowska , Maria Dzierżyńska , Sylwia Rodziewicz-Motowidło , Michał Pikuła

Abstract

During recent decades, the market for peptide-based drugs, including antimicrobial peptides, has vastly extended and evolved. These drugs can be useful in treatment of various types of disorders, e.g., cancer, autoimmune diseases, infections, and non-healing wounds. Although peptides are less immunogenic than other biologic therapeutics, they can still induce immune responses and cause allergies. It is important to evaluate the immunogenic and allergic potential of peptides before they are forwarded to the expensive stages of clinical trials. The process of the evaluation of immunogenicity and cytotoxicity is complicated, as in vitro models and bioinformatics tools cannot fully simulate situations in the clinic. Nevertheless, several potentially promising tests for the preclinical evaluation of peptide drugs have been implemented (e.g., cytotoxicity assays, the basophil activation test, and lymphocyte activation assays). In this review, we focus on strategies for evaluation of the allergic potential of peptide-based therapeutics.
Author Milena Deptuła
Milena Deptuła,,
-
, Anna Wardowska
Anna Wardowska,,
-
, Maria Dzierżyńska (FCh / DBCh / LMCh)
Maria Dzierżyńska,,
- Laboratory of Medical Chemistry
, Sylwia Rodziewicz-Motowidło (FCh / DBCh / LMCh)
Sylwia Rodziewicz-Motowidło,,
- Laboratory of Medical Chemistry
, Michał Pikuła
Michał Pikuła,,
-
Journal seriesMolecules, ISSN , e-ISSN 1420-3049, (A 30 pkt)
Issue year2018
Vol23
No2
Pages1-9
DOIDOI:10.3390/molecules23020414
URL http://www.mdpi.com/1420-3049/23/2/414/pdf
Languageen angielski
LicenseJournal (articles only); published final; Uznanie Autorstwa (CC-BY); with publication
Score (nominal)30
ScoreMinisterial score = 30.0, 26-11-2018, ArticleFromJournal
Ministerial score (2013-2016) = 30.0, 26-11-2018, ArticleFromJournal
Publication indicators WoS Impact Factor: 2016 = 2.861 (2) - 2016=2.988 (5)
Citation count*
Cite
Share Share

Get link to the record


* presented citation count is obtained through Internet information analysis and it is close to the number calculated by the Publish or Perish system.
Back