Introduction of non-natural amino acid residues into the substrate-specific P1 position of trypsin inhibitor SFTI-1 yields potent chymotrypsin and cathepsin G inhibitors

Anna Łęgowska , Dawid Dębowski , Adam Lesner , Magdalena Wysocka , Krzysztof Rolka

Abstract

n/a
Author Anna Łęgowska (FCh / DMB / LBCh)
Anna Łęgowska,,
- Laboratory of Bioorganic Chemistry
, Dawid Dębowski (FCh / DMB / LBCh)
Dawid Dębowski,,
- Laboratory of Bioorganic Chemistry
, Adam Lesner (FCh / DMB / LBA)
Adam Lesner,,
- Laboratory of Biochemical Analytics
, Magdalena Wysocka (FCh / DMB / LBCh)
Magdalena Wysocka,,
- Laboratory of Bioorganic Chemistry
, Krzysztof Rolka (FCh / DMB / LBCh)
Krzysztof Rolka,,
- Laboratory of Bioorganic Chemistry
Journal seriesBioorganic & Medicinal Chemistry, ISSN 0968-0896, (A 25 pkt)
Issue year2009
Vol17
No9
Pages3302-3307
Keywords in Englishinhibitors, peptides, chemical synthesis, cathepsin G, chymotrypsin, phenylalanine derivatives
DOIDOI:10.1016/j.bmc.2009.03.045
URL http://dx.doi.org/10.1016/j.bmc.2009.03.045
Languageen angielski
Score (nominal)30
Publication indicators WoS Impact Factor: 2009 = 2.822 (2) - 2009=3.046 (5)
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