Thiamine diphosphate status and dialysis-related losses in end-stage kidney disease patients treated with hemodialysis

Magdalena Jankowska , Paweł Rudnicki-Velasquez , Hanna Storoniak , Bolesław Rutkowski , Karol Krzymiński , Alicja Dębska-Ślizień


Aim: (1) To describe the whole blood content of thiamine diphosphate (TDP), a biologically active form of vitamin B1 in end-stage kidney disease patients treated with hemodialysis (HD); (2) to establish the impact of a single HD procedure on TDP blood concentrations; and (3) to describe potential explanatory variables influencing TDP dialysis related losses, including dialysis prescription, vitamin B1 dietary intake and supplementation. Methods: Single-center, cross-sectional study in 50 clinically stable maintenance HD patients. The assessment of whole blood TDP with the High Performance Liquid Chromatography method, before and after a single, middle-week dialysis session and analysis of clinical and laboratory parameters potentially influencing TDP status Results: We report a significant difference in TDP levels before and after HD sessions – 42.5 (95% CI 38.7–46.2) μg/L and 23.6 (95% CI 18.9–28.2) μg/L, respectively ( p = 0.000). The magnitude of intradialytic TDP changes is highly variable among individuals and is negatively associated only with the body weight of the patients ( p < 0.013). Vitamin B1 dietary intake and supplementation do not influence whole blood TDP and dialysis-related loss of TDP. Conclusions: TDP, a bioactive compound of vitamin B1, is substantially lost during the HD procedure, and the magnitude of its loss is associated with the patient’s body weight but it is not influenced by vitamin B1 dietary intake and standard supplementation dose.
Author Magdalena Jankowska
Magdalena Jankowska,,
, Paweł Rudnicki-Velasquez (FCh / DPCh / LLR)
Paweł Rudnicki-Velasquez,,
- Laboratory of Luminescence Research
, Hanna Storoniak
Hanna Storoniak,,
, Bolesław Rutkowski
Bolesław Rutkowski,,
, Karol Krzymiński (FCh / DPCh / LLR)
Karol Krzymiński,,
- Laboratory of Luminescence Research
, Alicja Dębska-Ślizień
Alicja Dębska-Ślizień,,
Journal seriesBlood Purification, ISSN 0253-5068, (A 25 pkt)
Issue year2017
Publication size in sheets0.5
Keywords in Englishthiamine, hemodialysis, kidney, nutrition, supplementation
ASJC Classification2727 Nephrology; 2720 Hematology; 2700 General Medicine
Languageen angielski
Score (nominal)25
ScoreMinisterial score = 25.0, 24-07-2019, ArticleFromJournal
Publication indicators WoS Citations = 3; Scopus SNIP (Source Normalised Impact per Paper): 2016 = 0.663; WoS Impact Factor: 2017 = 1.919 (2) - 2017=1.892 (5)
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* presented citation count is obtained through Internet information analysis and it is close to the number calculated by the Publish or Perish system.