Primary degradation of antidiabetic drugs

Marta Markiewicz , Christian Jungnickel , Stefan Stolte , Anna Białk-Bielińska , Jolanta Kumirska , Wojciech Mrozik

Abstract

Type 2 diabetes is a chronic disease affecting a large portion of the world population and is treated by orally administered drugs. Since these drugs are often taken in high doses and are excreted unchanged or partially metabolised many of them are nowadays detected in surface waters or wastewater treatment plants effluents. Unmetabolised antidiabetics or some of their transformation products retain their pharmacological activity, therefore their presence in the environment is highly undesired. One of the main routes of elimination from wastewaters or surface waters is biodegradation. Within this work we tested primary biodegradation of: metformin and its metabolite guanylurea, acarbose, glibenclamide, gliclazide and glimepiride. We also inspected what might be the extent of the degradation by examining the products formed during the degradation using liquid chromatography coupled to tandem mass spectrometry. Transformation of diabetes staple drug metformin to dead-end product guanylurea was generally confirmed. An alternative, though rather minor pathway leading to complete mineralisation was also found. Complete primary degradation was observed for acarbose, glibenclamide and glimepiride whereas gliclazide was shown to be resistant to biodegradation. These results allow a preliminary assessment of environmental persistency of a very important group of pharmaceuticals and show need for implementing monitoring programs.
Author Marta Markiewicz - [University of Bremen]
Marta Markiewicz,,
-
- University of Bremen
, Christian Jungnickel - [Politechnika Gdanska]
Christian Jungnickel,,
-
- Politechnika Gdanska
, Stefan Stolte (FCh / DEA / LChER)
Stefan Stolte,,
- Laboratory of Chemical Environmental Risks
, Anna Białk-Bielińska (FCh / DEA / LChER)
Anna Białk-Bielińska,,
- Laboratory of Chemical Environmental Risks
, Jolanta Kumirska (FCh / DEA / LChAD)
Jolanta Kumirska,,
- Laboratory of Chemical Analytics and Diagnostics
, Wojciech Mrozik - [Newcastle University, United Kingdom]
Wojciech Mrozik,,
-
- Newcastle University, United Kingdom
Journal seriesJournal of Hazardous Materials, ISSN 0304-3894, (A 45 pkt)
Issue year2017
Vol324
NoB
Pages428-435
Publication size in sheets0.5
Keywords in Englishprimary biodegradation, pharmaceuticals, antidiabetic drugs, sulphonamides, environmental fate
ASJC Classification2304 Environmental Chemistry; 2305 Environmental Engineering; 2307 Health, Toxicology and Mutagenesis; 2310 Pollution; 2311 Waste Management and Disposal
DOIDOI:10.1016/j.jhazmat.2016.11.008
URL http://dx.doi.org/10.1016/j.jhazmat.2016.11.008
Languageen angielski
Not used for evaluationyes
Score (nominal)0
Publication indicators WoS Citations = 14; Scopus Citations = 23; Scopus SNIP (Source Normalised Impact per Paper): 2017 = 1.988; WoS Impact Factor: 2017 = 6.434 (2) - 2017=6.513 (5)
Citation count*28 (2020-05-23)
Additional fields
UwagiArtykuł został zgłoszony do parametryzacji za lata 2013-2016
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* presented citation count is obtained through Internet information analysis and it is close to the number calculated by the Publish or Perish system.
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