Comparison of the usefulness of SPE cartridges for the determination of β-blockers and β-agonists (basic drugs) in environmental aqueous samples

Magda Caban , Piotr Stepnowski , Marek Kwiatkowski , Joanna Maszkowska , Marta Wagil , Jolanta Kumirska

Abstract

Even though the methodology used for the determination of β-blockers and β-agonists in environmental samples is based mainly on solid-phase extraction (SPE) and gas chromatography or liquid chromatography with mass spectrometric detection, the available literature data on the applied SPE procedures is rather sparse. In this paper such comparison is presented. Moreover, the usefulness of the eight SPE cartridges for the determination of five β-blockers (acebutolol, atenolol, metoprolol, nadolol, and propranolol) and two β-agonists (salbutamol and terbutaline) in environmental aqueous samples using GC techniques is tested. Among them, three (the trifunction sorbent Strata Screen C, the copolymers LiChrolut EN, and the functionalized copolymer Isolute ENV+) were used for the first time for this purpose. It was confirmed that polystyrene-divinylbenzene-N-vinylpyrrolidone copolymers (PS-DVB-VP, Strata-X, and Oasis HLB cartridges) have a better potential than a cation-exchange sorbent for the extraction of the target drugs from environmental water samples. However, it should be stressed out that the direct application of the tested SPE conditions for the analysis of real environmental water samples is not possible, and such parameters, like volume of loading sample, appropriate solvents for washing and elution steps, and so forth, must be optimized again in order to achieve satisfactory recovery values for the target compounds.
Author Magda Caban (FCh / DEA / PAiMŚ)
Magda Caban,,
- Pracownia Analityki i Monitoringu Środowiska
, Piotr Stepnowski (FCh / DEA / LChER)
Piotr Stepnowski,,
- Laboratory of Chemical Environmental Risks
, Marek Kwiatkowski (FCh / DDPS)
Marek Kwiatkowski,,
- Division of Didactics and Popular Science
, Joanna Maszkowska (FCh / DEA / LChER)
Joanna Maszkowska,,
- Laboratory of Chemical Environmental Risks
, Marta Wagil (FCh / DEA / LChER)
Marta Wagil ,,
- Laboratory of Chemical Environmental Risks
, Jolanta Kumirska (FCh / DEA / LChAD)
Jolanta Kumirska,,
- Laboratory of Chemical Analytics and Diagnostics
Journal seriesJournal of Chemistry, ISSN 2090-9063, (A 20 pkt)
Issue year2015
Vol2015
Pages1-9
Publication size in sheets0.5
DOIDOI:10.1155/2015/195280
URL http://dx.doi.org/10.1155/2015/195280
Languageen angielski
LicenseJournal (articles only); published final; Uznanie Autorstwa (CC-BY); with publication
Score (nominal)20
ScoreMinisterial score = 20.0, 05-11-2018, ArticleFromJournal
Ministerial score (2013-2016) = 20.0, 05-11-2018, ArticleFromJournal
Publication indicators Scopus Citations = 2; WoS Impact Factor: 2015 = 0.996 (2) - 2015=1.074 (5)
Citation count*4 (2018-11-18)
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* presented citation count is obtained through Internet information analysis and it is close to the number calculated by the Publish or Perish system.
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