Changes in lipids composition and metabolism in colorectal cancer: a review
Alicja Pakiet , Jarosław Kobiela , Piotr Stepnowski , Tomasz Śledziński , Adriana Mika
AbstractAltered metabolism of lipids is currently considered a hallmark characteristic of many malignancies, including colorectal cancer (CRC). Lipids are a large group of metabolites that differ in terms of their fatty acid composition. This review summarizes recent evidence, documenting many alterations in the content and composition of fatty acids, polar lipids, oxylipins and triacylglycerols in CRC patients’ sera, tumor tissues and adipose tissue. Some of altered lipid molecules may be potential biomarkers of CRC risk, development and progression. Owing to a significant role of many lipids in cancer cell metabolism, some of lipid metabolism pathways may also constitute specific targets for anti-CRC therapy.
|Journal series||Lipids in Health and Disease, ISSN 1476-511X, (N/A 70 pkt)|
|Publication size in sheets||1|
|Keywords in English||Colorectal cancer, polar lipids, oxylipins, fatty acids, lipidomics, metabolism|
|ASJC Classification||; ; ;|
|License||Journal (articles only); published final; ; with publication|
|Score||= 70.0, 06-12-2019, ArticleFromJournal|
|Publication indicators||= 4; = 4; : 2017 = 0.815; : 2018 = 2.651 (2) - 2018=2.678 (5)|
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